Results 71 to 80 of about 36,012 (161)

Multiscale computational analysis reveals enhanced allosteric modulation of Nav1.5 by dual binding of dapagliflozin and ertugliflozin. [PDF]

Sci Rep
Chattopadhyay A, Fatehi M, Mosa FES, Gruber B, Light PE, Barakat K.   +5 more
europepmc   +1 more source

Activation of a Secondary-Messenger Receptor via Allosteric Modulation of a Dynamic Conformational Ensemble. [PDF]

Angew Chem Int Ed Engl
Söldner B, Singh H, Akoury E, Witte G, Linser R.   +4 more
europepmc   +1 more source

Enhancement of hippocampal interneuron excitability by NMDA receptor positive allosteric modulation. [PDF]

J Physiol
Xing H, Banke TG, Zhang L, Yu K, Camp CR, Fritzemeier RG, Akins NS, Paladugu S, Arcoria PJ, Brady BR, Prikhodko O, Kennedy MJ, Liotta DC, Yuan H, Traynelis SF.   +14 more
europepmc   +1 more source

Negative allosteric modulation of mGlu7 disrupts fear memory reconsolidation and glutamatergic signaling in rat and human brain tissue. [PDF]

Mol Psychiatry
Ciobanu AC, Caseiro DM, Niu R, Triana Del Rio R, Leroux C, Stefanelli A, Nakandakare CF, Pralong E, Daniel RT, Lütjens R, van den Burg EH, Stoop R.   +11 more
europepmc   +1 more source

Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake. [PDF]

J Clin Invest
Damm-Ganamet KL, Moon C, Wickenden AD, Tichenor M, Ge Y, Mercado-Marin EV, Chiou B, Manughian-Peter A, Mirzadegan T, Venable JD, Xavier RJ, Towne JE, Graham DB, Perrigoue J.   +13 more
europepmc   +1 more source

Allosteric modulation of Grb2 drives ligand-dependent signal responses. [PDF]

Biol Direct
Di Felice M, Rolfi LR, Toso J, Pennacchietti V, Ventura ES, Toto A, Tramutola A, Gianni S.   +7 more
europepmc   +1 more source

Functional spectrum of USP7 pathogenic variants in Hao-Fountain syndrome: Insights into the enzyme's activity, stability, and allosteric modulation. [PDF]

Proc Natl Acad Sci U S A
Korchak EJ, Sharafi M, Jaen Maisonet I, Salazar-Chaparro A, Semenova IV, Khan H, O'Neil AL, Caro P, Schaaf CP, Buhrlage SJ, Bezsonova I.   +10 more
europepmc   +1 more source

Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases. [PDF]

Am J Respir Cell Mol Biol
Shah SD, Deshpande DA.
europepmc   +1 more source

Bitopic A₃ Adenosine Receptor Molecular Probes: Positive Allosteric Modulation and Noncanonical Activation. [PDF]

J Med Chem
Kurma SH, Pavan M, Wan TC, Pradhan B, López-Cano M, Ciruela F, Gao ZG, Auchampach JA, Jacobson KA.   +8 more
europepmc   +1 more source

Mechanisms underlying allosteric modulation of antiseizure medication binding to synaptic vesicle protein 2A (SV2A). [PDF]

Proc Natl Acad Sci U S A
Mittal A, Martin MF, Provins L, Hall A, Ledecq M, Wolff C, Gillard M, Horanyi PS, Coleman JA.   +8 more
europepmc   +1 more source