Results 271 to 280 of about 139,314 (301)

Allosteric Modulators

2006
openaire   +2 more sources

Allosteric Modulators

2017
S. Lu, J. Zhang
openaire   +1 more source

Identification of dual role of piperazine-linked phenyl cyclopropyl methanone as positive allosteric modulator of 5-HT and negative allosteric modulator of 5-HT receptors

European Journal of Medicinal Chemistry, 2019
Mohammad Imran Siddiqi, Prem N Yadav, Ajeet Kumar   +2 more
exaly  

Pharmacokinetic and pharmacodynamic characterisation of JNJ-40411813, a positive allosteric modulator of mGluR2, in two randomised, double-blind phase-I studies

Journal of Psychopharmacology, 2015
Luc van Nueten
exaly  

Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7

Cell Chemical Biology, 2019
Dongxu Li, Kenneth H Pearce, Huitao Fan
exaly  

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Bioorganic and Medicinal Chemistry Letters, 2009
Colleen M. Niswender, Kari A Johnson, Craig W. Lindsley   +2 more
exaly  

An orally bioavailable positive allosteric modulator of the mGlu receptor with efficacy in an animal model of motor dysfunction

Bioorganic and Medicinal Chemistry Letters, 2010
Bastian Hengerer, Ralf Heilker, Mark J Gemkow   +2 more
exaly  

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA receptor positive allosteric modulator

Neuropharmacology, 2020
Paul A. Davies, Francesco G Salituro, Amit Modgil   +2 more
exaly  

Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABA receptors

Biochemical Pharmacology, 2018
Anders A Jensen, Nawid Madjroh
exaly  

Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator

European Journal of Pharmacology, 2011
Jeffrey S Smith, Patricia Schroeder
exaly