Results 121 to 130 of about 63,430 (242)

A Pathogenic Linked Mutation in the Catalytic Core of Human Cystathionine β-Synthase Disrupts Allosteric Regulation and Allows Kinetic Characterization of a Full-Length Dimer [PDF]

, 2007
Suvajit Sen, Ruma Banerjee
openalex   +1 more source

Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases

ChemBioChem, EarlyView.
GA: Genetically encoded internal electrophiles in ubiquitin (Ub) enable the profiling of multivalent interaction interfaces, addressing a key limitation of current Ub‐based activity‐based probes. In this study, these probes capture a Ub–deubiquitinase interaction with minimal structural perturbation and serve as selective diUb probes that covalently ...
Nipuni M. Pannala, Rishi S. Patel, Abhijith Saseendran Anit, Debapriya Bhattacharya, Kristos Negron Teron, Bryon Drown, Rudi Fasan, Chittaranjan Das   +7 more
wiley   +1 more source

Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2. [PDF]

Nat Commun
Kugawa M, Kawakami K, Kise R, Suomivuori CM, Tsujimura M, Kobayashi K, Kojima A, Inoue WJ, Fukuda M, Matsui TE, Fukunaga A, Koyanagi J, Kim S, Ikeda H, Yamashita K, Saito K, Ishikita H, Dror RO, Inoue A, Kato HE.   +19 more
europepmc   +1 more source

Loss of allosteric regulation in α-isopropylmalate synthase identified as an antimicrobial resistance mechanism. [PDF]

NPJ Antimicrob Resist, 2023
Sullivan JR, Courtine C, Taylor L, Solomon O, Behr MA.   +4 more
europepmc   +1 more source

Structural Basis for Allosteric Substrate Specificity Regulation in Anaerobic Ribonucleotide Reductases

, 2001
Karl-Magnus Larsson, Jessica Andersson, Britt‐Marie Sjöberg, P. Nordlund, Derek T. Logan   +4 more
openalex   +1 more source

Identification of Regions Critically Affecting Kinetics and Allosteric Regulation of theEscherichia coliADP-Glucose Pyrophosphorylase by Modeling and Pentapeptide-Scanning Mutagenesis [PDF]

, 2007
Miguel A. Ballícora, Esteban Erben, Terutaka Yazaki, Ana L. Ferreira Bertolo, Ana M. Demonte, Jennifer R. Schmidt, Mabel Aleanzi, Clarisa Maria Bejar, Carlos M. Figueroa, Corina M. Fusari, Alberto Á. Iglesias, Jack Preiss   +11 more
openalex   +1 more source

Investigating the Interaction Profile of Unconjugated Ubiquitin: Chemical Biology and Affinity Enrichment Mass Spectrometric Approaches

ChemBioChem, EarlyView.
This mini review provides insights into the synergistic power of chemical biology techniques for generating defined ubiquitin (Ub) variants and the use of affinity enrichment mass spectrometry to decipher the Ub code. It focuses on unconjugated Ub variants, which have emerged as additional signaling molecules in the Ub lexicon. Furthermore, it outlines
Simon Maria Kienle, Katrin Stuber
wiley   +1 more source

Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy. [PDF]

Biomolecules
Goričan T, Golič Grdadolnik S.
europepmc   +1 more source

Structure, Function, and Allosteric Regulation of the 20S Proteasome by the 11S/PA28 Family of Proteasome Activators. [PDF]

Biomolecules, 2023
Thomas T, Salcedo-Tacuma D, Smith DM.
europepmc   +1 more source

Structural Analysis of the Bacterial HPr Kinase/Phosphorylase V267F Mutant Gives Insights into the Allosteric Regulation Mechanism of This Bifunctional Enzyme [PDF]

, 2007
Vincent Chaptal, Fanny Vincent, Virginie Gueguen‐Chaignon, Vicente Monedero, Sandrine Poncet, Josef Deutscher, Sylvie Nessler, S. Moréra   +7 more
openalex   +1 more source