Results 171 to 180 of about 67,162 (289)

Disease-causing cystathionine β-synthase linker mutations impair allosteric regulation. [PDF]

J Biol Chem, 2023
Roman JV, Mascarenhas R, Ceric K, Ballou DP, Banerjee R.   +4 more
europepmc   +1 more source

High Km soluble 5′-nucleotidase from human placenta. Properties and allosteric regulation by IMP and ATP.

, 1988
Jarosław Spychała, Vicente Madrid‐Marina, I. H. Fox   +2 more
openalex   +1 more source

Allosteric Regulation of Bk Channel Gating by Ca2+ and Mg2+ through a Nonselective, Low Affinity Divalent Cation Site [PDF]

, 2001
X. Zhang, Christopher R. Solaro, Christopher J. Lingle   +2 more
openalex   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, EarlyView.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

Allosteric regulation of Senecavirus A 3Cpro proteolytic activity by an endogenous phospholipid. [PDF]

PLoS Pathog, 2023
Zhao HF, Meng L, Geng Z, Gao ZQ, Dong YH, Wang HW, Zhang H.   +6 more
europepmc   +1 more source

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction [PDF]

, 2019
Brent W. Anderson, Kuanqing Liu, Christine Wolak, Katarzyna Dubiel, Kenneth A. Satyshur, James L. Keck, Jue D. Wang   +6 more
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

ATP-Driven Allosteric Regulation of 14-3-3: Positive Modulation of ATP Hydrolysis and Negative Regulation of Peptide Binding. [PDF]

FASEB J
Bagdiya P, Soni N, Jaiswal D, Dalvi S, Kanitkar T, Madhusudhan MS, Venkatraman P.   +6 more
europepmc   +1 more source

Allosteric Regulation of the Soluble Epoxide Hydrolase by Nitro Fatty Acids: a Combined Experimental and Computational Approach

, 2022
Qiongju Qiu, Giancarlo Abis, Florence Mattingly-Peck, Steven Lynham, Franca Fraternali, Maria R. Conte   +5 more
openalex   +1 more source

Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley   +1 more source