Results 171 to 180 of about 130,849 (328)

Allosteric regulation of kinase activity in living cells. [PDF]

Elife, 2023
Godbole SS, Dokholyan NV.
europepmc   +1 more source

Transient Allosteric Regulation of Catalysis by Effector Switching in a Pt₂L₄ Cage [PDF]

Joost N. H. Reek, Zoe Ashbridge
openalex   +1 more source

Allosteric Chiral Recognition of Eu(III) Complex for Chiral Co(III) Complex Observed by Time‐Resolved Circularly Polarized Luminescence Spectroscopy

ChemistryEurope, EarlyView.
[Eu(pda)2]− (pda = 1,10‐phenanthroline‐2, 9‐dicarboxylic acid) containing Δ/Λ‐[Co(en)3]3+ (en = ethylenediamine) exhibits CPL signals (|glum| ≈0.2 at maximum) at the f–f transition in [Eu(pda)2]−. The time‐resolved CPL reveals that the short‐lived components exhibit CPL.
Juri Yamashita, Munetaka Iwamura, Tsukasa Takanashi, Koichi Nozaki, Taro Tsubomura   +4 more
wiley   +1 more source

Future Perspective On Materials, Electrochemistry, and Cell Concepts for Redox‐Mediated CO2 Direct Air Capture Scenarios

ChemistryEurope, EarlyView.
Direct air capture (DAC) of carbon dioxide (CO2) emerges as a key strategy for climate crisis mitigation. Redox‐mediated electrochemical carbon capture offers a promising route for energy‐efficient DAC. This perspective discusses recent advances in the field, highlighting key challenges, such as oxygen interference at low CO2 concentrations, and ...
Tilmann J. Neubert, Martin Oschatz
wiley   +1 more source

Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. [PDF]

Nucleic Acids Res, 2023
Lu J, Fang J, Zhu H, Liang KL, Khudaverdyan N, Song J.   +5 more
europepmc   +1 more source

Small‐Molecule Sarco/Endoplasmic Reticulum Ca2+‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms

ChemMedChem, EarlyView.
Endoplasmic reticulum (ER) Ca2+ dysregulation drives β‐cell dysfunction under diabetic stressors like methylglyoxal, which inhibits the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) pump through oxidative modifications. We show that synthetic SERCA activators restore pump activity after methylglyoxal‐induced damage.
Carlos Cruz‐Cortés, Silvia Micháliková, Petronela Rezbáriková, L. Michel Espinoza‐Fonseca, Jana Viskupičová   +4 more
wiley   +1 more source

The Pathway to Proof‐of‐Concept for BNC210, a Negative Allosteric Modulator of the Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease

Clinical Pharmacology in Drug Development, EarlyView.
Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan, Elizabeth Doolin, Dharam Paul, Julia Crossman, Michael Odontiadis, Philippe Danjou, Mark Smith, Spyros Papapetropoulos   +7 more
wiley   +1 more source

Biophysical Mechanism of Allosteric Regulation of Actin Capping Protein. [PDF]

J Mol Biol, 2023
Mooren OL, Stuchell-Brereton MD, McConnell P, Yan C, Wilkerson EM, Goldfarb D, Cooper JA, Sept D, Soranno A.   +8 more
europepmc   +1 more source

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Allosteric Regulation of Bk Channel Gating by Ca2+ and Mg2+ through a Nonselective, Low Affinity Divalent Cation Site [PDF]

, 2001
X. Zhang, Christopher R. Solaro, Christopher J. Lingle   +2 more
openalex   +1 more source