Results 261 to 270 of about 2,237,466 (287)
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Allosteric regulation of purine nucleoside phosphorylase
Archives of Biochemistry and Biophysics, 1991Purine nucleoside phosphorylase (EC 2.4.2.1) from bovine spleen is allosterically regulated. With the substrate inosine the enzyme displayed complex kinetics: positive cooperativity vs inosine when this substrate was close to physiological concentrations, negative cooperativity at inosine concentrations greater than 60 microM, and substrate inhibition ...
P A, Ropp, T W, Traut
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DNA as an Allosteric Regulator
Science Signaling, 2009The sequence of the DNA binding site affects the transcriptional regulatory activity of the glucocorticoid receptor.
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Allosteric regulation of Warts
Science Signaling, 2016Hippo pathway regulators allosterically switch the conformation of the kinase Warts.
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Nucleosomes as allosteric scaffolds for genetic regulation
Current Opinion in Structural Biology, 2020Nucleosomes are stable yet highly dynamic complexes exhibiting diverse types of motions, such as sliding, DNA unwrapping, and disassembly, encoding a landscape with a large number of metastable states. In this review, describing recent studies on these nucleosome structure changes, we propose that the nucleosome can be viewed as an ideal allosteric ...
Shoji Takada +2 more
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Allosteric effects of DNA on transcriptional regulators
Nature, 1998Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is ...
J A, Lefstin, K R, Yamamoto
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Design of Allosterically Regulated Protein Catalysts
Biochemistry, 2015Activity of allosteric protein catalysts is regulated by an external stimulus, such as protein or small molecule binding, light activation, pH change, etc., at a location away from the active site of the enzyme. Since its original introduction in 1961, the concept of allosteric regulation has undergone substantial expansion, and many, if not most ...
Olga V, Makhlynets +2 more
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Dynamic Protein Allosteric Regulation and Disease
2019Allostery is largely associated with conformational and functional transitions in individual proteins. All dynamic proteins are allosteric. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states.
Ruth, Nussinov +2 more
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Allosteric regulation of the cAMP receptor protein
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2001The cyclic AMP receptor protein (CRP) of Escherichia coli is a dimer made up of identical subunits. Each CRP subunit contains a cyclic nucleotide binding pocket and the CRP dimer exhibits negative cooperativity in binding cAMP. In solutions containing cAMP, CRP undergoes sequential conformation changes from the inactive apo-form through the active CRP:(
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Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes
Cell, 2021Yang Du, Shengyong Yang, Liangliang Kong
exaly
An Allosterically Regulated Molecular Shuttle
Angewandte Chemie International Edition, 2006Dana S, Marlin +3 more
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