Results 251 to 260 of about 2,237,466 (287)

Engineering Allosteric Regulation into Biological Catalysts

ChemBioChem, 2009
Enzymes and ribozymes constitute two biological catalysts. The activity of many natural enzymes is regulated by the binding of ligands that have different structures than their substrates; these ligands are consequently called allosteric effectors.
Jacques Fastrez
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

NADPH Is an Allosteric Regulator of HSCARG

Journal of Molecular Biology, 2009
NADP(H) is an important cofactor that controls many fundamental cellular processes. We have determined the crystal structure of HSCARG, a novel NADPH sensor, and found that it forms an asymmetrical dimer with only one subunit occupied by an NADPH molecule, and the two subunits have dramatically different conformations.
Xueyu, Dai, Yiyu, Li, Geng, Meng, Shun, Yao, Yanmei, Zhao, Quan, Yu, Jinfang, Zhang, Ming, Luo, Xiaofeng, Zheng   +8 more
openaire   +2 more sources

Allosteric regulation of phosphoribulokinase activity

Biochemical and Biophysical Research Communications, 1968
Inhibition of ATP-dependent CO2 fixation by AMP has been reported in several autotrophic organisms (Johnson and Peck, 1965; Mayeux and Johnson, 1966;Johnson, 1966; Gale and Beck, 1966). Johnson (1966) suggested that the site of AMP inhibition is phosphoribulokinase and that inhibition may occur through allosteric modification of the enzyme. In contrast,
R D, MacElroy, E J, Johnson, M K, Johnson   +2 more
openaire   +2 more sources

The role of dynamics in allosteric regulation

Current Opinion in Structural Biology, 2003
The biomolecular conformational changes often associated with allostery are, by definition, dynamic processes. Recent publications have disclosed the role of pre-existing equilibria of conformational substates in this process. In addition, the role of dynamics as an entropic carrier of free energy of allostery has been investigated.
Dorothee, Kern, Erik R P, Zuiderweg
openaire   +2 more sources

Allosteric regulation and inhibition of protein kinases

Biochemical Society Transactions, 2023
The human genome encodes more than 500 different protein kinases: signaling enzymes with tightly regulated activity. Enzymatic activity within the conserved kinase domain is influenced by numerous regulatory inputs including the binding of regulatory domains, substrates, and the effect of post-translational modifications such as autophosphorylation ...
Victoria R. Mingione, YiTing Paung, Ian R. Outhwaite, Markus A. Seeliger   +3 more
openaire   +2 more sources

Allosteric regulation of crocodilian haemoglobin

Nature, 1981
The oxygen affinity of most vertebrate haemoglobins in the absence of diffusible electrolytes is much higher than that of blood. In the red cell this affinity is lowered by organic phosphates, hydrogen ions, chloride ions and CO2 (refs 1–5). Similarly, crocodilian haemoglobin also has a much higher oxygen affinity than crocodile blood, but this is due ...
Perutz, Max M.F., Bauer, Christian, Gros, Gerolf, Leclercq, Françoise, Vandecasserie, Christian, Schnek, Arthur Georges, Braunitzer, Gerhard, Friday, Adrian A.E., Joysey, Kenneth Alan   +8 more
openaire   +3 more sources

Allosteric regulation of platelet actomyosin

Biochemical and Biophysical Research Communications, 1973
Abstract The kinetic properties of platelet actomyosin have been examined to understand the mode of hydrolysis of its substrate ATP. In the presence of divalent cations, ATP hydrolysis deviated from Michaelis-Menten kinetics in such a way as to indicate cooperative effects, with a sigmoidal velocity vs.
M N, Malik, T C, Detwiler, A, Stracher
openaire   +2 more sources

Targeting allosteric regulation of cancer metabolism

Nature Chemical Biology, 2022
Metabolic reprogramming is observed across all cancer types. Indeed, the success of many classic chemotherapies stems from their targeting of cancer metabolism. Contemporary research in this area has refined our understanding of tumor-specific metabolic mechanisms and has revealed strategies for exploiting these vulnerabilities selectively.
Daniel M. Kremer, Costas A. Lyssiotis
openaire   +2 more sources

Engineered Allosteric Regulation of Protein Function

Journal of Molecular Biology, 2022
Allosteric regulation of proteins has been utilized to study various aspects of cell signaling, from unicellular events to organism-wide phenotypes. However, traditional methods of allosteric regulation, such as constitutively active mutants and inhibitors, lack tight spatiotemporal control.
Jordan, Fauser, Nicholas, Leschinsky, Barbara N, Szynal, Andrei V, Karginov   +3 more
openaire   +2 more sources

Allosteric Regulation of Chromatin-Modifying Enzymes

Biochemistry, 2018
Dynamic changes in chromatin structure are crucial for diverse biological processes. Given the complexity of the epigenetic landscape, understanding the specificity of chromatin modification has been a major interest in the epigenetics field. Recent progress in biochemical and structural analyses in the field of chromatin biology has revealed that ...
Jung-Ae Kim, Minjung Kwon, Jaehoon Kim
openaire   +2 more sources