Results 301 to 310 of about 130,849 (328)
Some of the next articles are maybe not open access.
Allosteric Regulation of Proteases
ChemBioChem, 2008AbstractAllostery is a basic principle of control of enzymatic activities based on the interaction of a protein or small molecule at a site distinct from an enzyme's active center. Allosteric modulators represent an alternative approach to the design and synthesis of small‐molecule activators or inhibitors of proteases and are therefore of wide ...
Hauske, Patrick +4 more
openaire +3 more sources
Allosteric regulation of chaperonins
Current Opinion in Structural Biology, 2005Chaperonins are molecular machines that facilitate protein folding by undergoing energy (ATP)-dependent movements that are coordinated in time and space by complex allosteric regulation. Recently, progress has been made in describing the various functional (allosteric) states of these machines, the pathways by which they interconvert, and the coupling ...
Horovitz, A, Willison, KR
openaire +3 more sources
How protein topology controls allosteric regulations
The Journal of Chemical Physics, 2023Allostery is an important regulatory mechanism of protein functions. Among allosteric proteins, certain protein structure types are more observed. However, how allosteric regulation depends on protein topology remains elusive. In this study, we extracted protein topology graphs at the fold level and found that known allosteric proteins mainly contain ...
Juan Xie +3 more
openaire +2 more sources
Aptamers for allosteric regulation
Nature Chemical Biology, 2011Aptamers are useful for allosteric regulation because they are nucleic acid-based structures in which ligand binding induces conformational changes that may alter the function of a connected oligonucleotide at a distant site. Through this approach, a specific input is efficiently converted into an altered output.
Vinkenborg, J. +2 more
openaire +3 more sources
Allosteric regulation of phosphoribulokinase activity
Biochemical and Biophysical Research Communications, 1968Inhibition of ATP-dependent CO2 fixation by AMP has been reported in several autotrophic organisms (Johnson and Peck, 1965; Mayeux and Johnson, 1966;Johnson, 1966; Gale and Beck, 1966). Johnson (1966) suggested that the site of AMP inhibition is phosphoribulokinase and that inhibition may occur through allosteric modification of the enzyme. In contrast,
R D, MacElroy +2 more
openaire +2 more sources
Allosteric regulation of crocodilian haemoglobin
Nature, 1981The oxygen affinity of most vertebrate haemoglobins in the absence of diffusible electrolytes is much higher than that of blood. In the red cell this affinity is lowered by organic phosphates, hydrogen ions, chloride ions and CO2 (refs 1–5). Similarly, crocodilian haemoglobin also has a much higher oxygen affinity than crocodile blood, but this is due ...
Perutz, Max M.F. +8 more
openaire +2 more sources
Allosteric regulation of platelet actomyosin
Biochemical and Biophysical Research Communications, 1973Abstract The kinetic properties of platelet actomyosin have been examined to understand the mode of hydrolysis of its substrate ATP. In the presence of divalent cations, ATP hydrolysis deviated from Michaelis-Menten kinetics in such a way as to indicate cooperative effects, with a sigmoidal velocity vs.
M N, Malik, T C, Detwiler, A, Stracher
openaire +2 more sources
Engineered Allosteric Regulation of Protein Function
Journal of Molecular Biology, 2022Allosteric regulation of proteins has been utilized to study various aspects of cell signaling, from unicellular events to organism-wide phenotypes. However, traditional methods of allosteric regulation, such as constitutively active mutants and inhibitors, lack tight spatiotemporal control.
Jordan, Fauser +3 more
openaire +2 more sources
Diversity of Allosteric Regulation in Proteases
ACS Chemical Biology, 2012Allostery is a fundamental regulatory mechanism that is based on a functional modulation of a site by a distant site. Allosteric regulation can be triggered by binding of diverse allosteric effectors, ranging from small molecules to macromolecules, and is therefore offering promising opportunities for functional modulation in a wide range of ...
Merdanovic, Melisa +3 more
openaire +3 more sources
Targeting allosteric regulation of cancer metabolism
Nature Chemical Biology, 2022Metabolic reprogramming is observed across all cancer types. Indeed, the success of many classic chemotherapies stems from their targeting of cancer metabolism. Contemporary research in this area has refined our understanding of tumor-specific metabolic mechanisms and has revealed strategies for exploiting these vulnerabilities selectively.
Daniel M. Kremer, Costas A. Lyssiotis
openaire +2 more sources