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Allosteric regulation of crocodilian haemoglobin
Nature, 1981The oxygen affinity of most vertebrate haemoglobins in the absence of diffusible electrolytes is much higher than that of blood. In the red cell this affinity is lowered by organic phosphates, hydrogen ions, chloride ions and CO2 (refs 1–5). Similarly, crocodilian haemoglobin also has a much higher oxygen affinity than crocodile blood, but this is due ...
Perutz, Max M.F. +8 more
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Allosteric regulation of platelet actomyosin
Biochemical and Biophysical Research Communications, 1973Abstract The kinetic properties of platelet actomyosin have been examined to understand the mode of hydrolysis of its substrate ATP. In the presence of divalent cations, ATP hydrolysis deviated from Michaelis-Menten kinetics in such a way as to indicate cooperative effects, with a sigmoidal velocity vs.
Thomas C. Detwiler +2 more
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DNA as an Allosteric Regulator
Science Signaling, 2009The sequence of the DNA binding site affects the transcriptional regulatory activity of the glucocorticoid receptor.
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Allosteric regulation of Warts
Science Signaling, 2016Hippo pathway regulators allosterically switch the conformation of the kinase Warts.
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The ribosome as an allosterically regulated molecular machine
Biochemistry (Moscow), 2017The ribosome as a complex molecular machine undergoes significant conformational rearrangements during the synthesis of polypeptide chains of proteins. In this review, information obtained using various experimental methods on the internal consistency of such rearrangements is discussed.
T. M. Makarova, Alexey A. Bogdanov
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Design of Allosterically Regulated Protein Catalysts
Biochemistry, 2015Activity of allosteric protein catalysts is regulated by an external stimulus, such as protein or small molecule binding, light activation, pH change, etc., at a location away from the active site of the enzyme. Since its original introduction in 1961, the concept of allosteric regulation has undergone substantial expansion, and many, if not most ...
Elizabeth A. Raymond +2 more
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Allosteric Regulation of Chromatin-Modifying Enzymes
Biochemistry, 2018Dynamic changes in chromatin structure are crucial for diverse biological processes. Given the complexity of the epigenetic landscape, understanding the specificity of chromatin modification has been a major interest in the epigenetics field. Recent progress in biochemical and structural analyses in the field of chromatin biology has revealed that ...
Jung-Ae Kim, Minjung Kwon, Jaehoon Kim
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Nucleosomes as allosteric scaffolds for genetic regulation
Current Opinion in Structural Biology, 2020Nucleosomes are stable yet highly dynamic complexes exhibiting diverse types of motions, such as sliding, DNA unwrapping, and disassembly, encoding a landscape with a large number of metastable states. In this review, describing recent studies on these nucleosome structure changes, we propose that the nucleosome can be viewed as an ideal allosteric ...
Shoji Takada +2 more
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Mechanism of Allosteric Regulation of Dnmt1's Processivity
Biochemistry, 2005We have analyzed the relationship between the allosteric regulation and processive catalysis of DNA methyltransferase 1 (Dnmt1). Processivity is described quantitatively in terms of turnover rate, DNA dissociation rate, and processivity probability. Our results provide further evidence that the active site and the allosteric sites on Dnmt1 can bind DNA
Norbert O. Reich +1 more
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Allosteric regulation of purine nucleoside phosphorylase
Archives of Biochemistry and Biophysics, 1991Purine nucleoside phosphorylase (EC 2.4.2.1) from bovine spleen is allosterically regulated. With the substrate inosine the enzyme displayed complex kinetics: positive cooperativity vs inosine when this substrate was close to physiological concentrations, negative cooperativity at inosine concentrations greater than 60 microM, and substrate inhibition ...
Patricia A. Ropp, Thomas W. Traut
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