Results 181 to 190 of about 2,925,762 (288)

<i>Lantana camara</i> L. (Verbenaceae) attenuates Ischemia-induced olfactory dysfunction by targeting the α7 nAChR allosteric site and mitigating oxidative-inflammatory cascades in the rat olfactory-memory axis. [PDF]

IBRO Neurosci Rep
Mabou ST, Bilanda CD, Kahou BRT, Meuladje FT, Kandeda AK.   +4 more
europepmc   +1 more source

CD40L Activates Platelet Integrin αIIbβ3 by Binding to the Allosteric Site (Site 2) in a KGD-Independent Manner and HIGM1 Mutations Are Clustered in the Integrin-Binding Sites of CD40L. [PDF]

Cells, 2023
Takada YK, Shimoda M, Takada Y.
europepmc   +1 more source

De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS. [PDF]

Nat Commun
Zhao W, Chen G, He J, Shen X, Xiong M, Xiong L, Qi Z, Xie H, Li W, Li J, Dou H, Hu H, Su H, Shao Q, Li M, Sun H, Xu Y.   +16 more
europepmc   +1 more source

Identification of Potential Allosteric Site Binders of Indoleamine 2,3-Dioxygenase 1 from Plants: A Virtual and Molecular Dynamics Investigation. [PDF]

Pharmaceuticals (Basel), 2022
de Almeida VM, Santos-Filho OA.
europepmc   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

AlloBench: A Data Set Pipeline for the Development and Benchmarking of Allosteric Site Prediction Tools. [PDF]

ACS Omega
Maity D, Qiao B.
europepmc   +1 more source

Integration of In Silico Strategies for Drug Repositioning towards P38α Mitogen-Activated Protein Kinase (MAPK) at the Allosteric Site. [PDF]

Pharmaceutics, 2022
Suriya U, Mahalapbutr P, Rungrotmongkol T.   +2 more
europepmc   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

DeepAllo: allosteric site prediction using protein language model (pLM) with multitask learning. [PDF]

Bioinformatics
Khokhar M, Keskin O, Gursoy A.
europepmc   +1 more source

Identification of a Novel Allosteric Site at the M₅ Muscarinic Acetylcholine Receptor. [PDF]

ACS Chem Neurosci, 2021
Burger WAC, Gentry PR, Berizzi AE, Vuckovic Z, van der Westhuizen ET, Thompson G, Yeasmin M, Lindsley CW, Sexton PM, Langmead CJ, Tobin AB, Christopoulos A, Valant C, Thal DM.   +13 more
europepmc   +1 more source