Results 121 to 130 of about 10,740 (213)
Native State Volume Fluctuations in Proteins as a Mechanism for Dynamic Allostery
, 2017 Allostery enables tight regulation of protein function in the cellular environment. Although existing models of allostery are firmly rooted in the current structure–function paradigm, the mechanistic basis for allostery in the absence of structural ...
Jun Zhang (48506) +4 more
core +1 more source
, 2015 SummaryLeukocyte CD18 integrins increase their affinity for ligand by transmitting allosteric signals to and from their ligand-binding αI domain. Mechanical forces induce allosteric changes that paradoxically slow dissociation by increasing the integrin ...
Thayer, Elizabeth +21 more
core +1 more source
DEVELOPMENT OF NOVEL COMPUTATIONAL METHODS FOR CHARACTERIZING PROTEIN ALLOSTERY
Many proteins cannot be adequately understood and drugged without considering allostery. Yet allostery is often difficult to study. Proteins of interest to me, such as the SARS-CoV-2 main protease, have remained poorly understood despite extensive ...
Evans, Daniel James
core +1 more source
Identifying Key Residues for Protein Allostery through Rigid Residue Scan
, 2016 : Allostery is a ubiquitous process for protein regulatory activity in which a binding event can change a protein’s function carried out at a distal site.
Jin Liu +5 more
core +1 more source
Controlled mechanochemical coupling of anti-junctions in DNA origami arrays
Nature CommunicationsAllostery is a hallmark of cellular function and important in every biological system. Still, we are only starting to mimic it in the laboratory. Here, we introduce an approach to study aspects of allostery in artificial systems.
Fiona Cole +5 more
doaj +1 more source
Evolution of allostery in isocitrate lyase
Allostery is crucial for regulating the activity of enzymes in many biochemical and physiological processes. In allostery, the binding of ligands in one site of a protein changes the binding or activity of another site on the protein.
Guo, Shuning
core
Allostery through protein-induced DNA bubbles
, 2015 Allostery through DNA is increasingly recognized as an important modulator of DNA functions. Here, we show that the coalescence of protein-induced DNA bubbles can mediate allosteric interactions that drive protein aggregation.
Rasmussen, Kim Ø +4 more
core +1 more source
UNDERSTANDING GENERALIZED ALLOSTERY IN THROMBIN
, 2018 Thrombin is a critical drug target for chemotherapeutic and antithrombotic therapy development. Although many experiments have demonstrated that thrombin is a multifunctional allosteric enzyme, the exact mechanism of thrombin's allostery is still unclear
Xiao, Jiajie
core
Protein Allostery Study in Cells Using NMR Spectroscopy
Protein allostery is commonly observed in vitro. But how protein allostery behaves in cells is unknown. In this work, a protein monomer–dimer equilibrium system was built with the allosteric effect on the binding characterized using NMR spectroscopy ...
Xiaoxu Chen (3816778) +8 more
core +1 more source
The Power of Protein Dynamics in Binding and Allostery. [PDF]
BiochemistryLee AL, Sapienza PJ.
europepmc +1 more source