Results 111 to 120 of about 18,856 (214)
Revealing structure-function relationships in functional flow networks via persistent homology
, 2019 Complex networks encountered in biology are often characterized by significant structural diversity. Whether it be differences in the three-dimensional structure of allosteric proteins, or the variation among the micro-scale structures of organisms ...
Katifori, Eleni +2 more
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Introduction to Protein Structure Prediction [PDF]
, 2017 This chapter gives a graceful introduction to problem of protein three- dimensional structure prediction, and focuses on how to make structural sense out of a single input sequence with unknown structure, the 'query' or 'target' sequence.
Abeln, Sanne +2 more
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Eigenvector Centrality Distribution for Characterization of Protein Allosteric Pathways
, 2018 Determining the principal energy pathways for allosteric communication in biomolecules, that occur as a result of thermal motion, remains challenging due to the intrinsic complexity of the systems involved.
Batista, Victor S. +8 more
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Dynamic regulation of phenylalanine hydroxylase
Pteridines, 2014 Phenylalanine hydroxylase (PAH) is the key enzyme in phenylalanine metabolism, catalyzing its oxidative breakdown to tyrosine. Its function in the committed step of amino acid metabolism requires strict regulation. Thus, several regulatory mechanisms are
Fuchs Julian E. +2 more
doaj +1 more source
Exploring allostery’s advantages [PDF]
C&EN Global Enterprise, 2019 Drug hunters have spent years cutting chemical keys to fit the most obvious biological locks: a protein’s active site, the spot where its natural substrate clicks in to turn it on or off. Walk into any big pharma company lab, and you will find the first step of that process: crane-like robotic arms pipetting tiny drops of compounds onto well plates ...
openaire +1 more source
Systematic mapping of protein‐metabolite interactions in central metabolism of Escherichia coli
Molecular Systems Biology, 2019 Metabolite binding to proteins regulates nearly all cellular processes, but our knowledge of these interactions originates primarily from empirical in vitro studies.
Maren Diether +3 more
doaj +1 more source
eLifeThe intuitive manipulation of specific amino acids to alter the activity or specificity of CRISPR-Cas9 has been a topic of great interest. As a large multi-domain RNA-guided endonuclease, the intricate molecular crosstalk within the Cas9 protein hinges ...
Helen B Belato +8 more
doaj +1 more source
Controlled mechanochemical coupling of anti-junctions in DNA origami arrays
Nature CommunicationsAllostery is a hallmark of cellular function and important in every biological system. Still, we are only starting to mimic it in the laboratory. Here, we introduce an approach to study aspects of allostery in artificial systems.
Fiona Cole +5 more
doaj +1 more source
Tuning transcriptional regulation through signaling: A predictive theory of allosteric induction
, 2017 Allosteric regulation is found across all domains of life, yet we still lack simple, predictive theories that directly link the experimentally tunable parameters of a system to its input-output response.
Barnes, Stephanie L. +6 more
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