Results 111 to 120 of about 10,740 (213)
Allosteric cross-talk in chromatin can mediate drug-drug synergy
Nature Communications, 2017 Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin ...
Zenita Adhireksan +7 more
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Allostery in an Ensemble [PDF]
Biophysical Journal, 2011 Over the past 50 years of structural biology research, three incontrovertible, and as yet not fully reconciled, aspects of protein behavior have emerged: First, protein molecules manifest a broad range of seemingly complex functions, ranging from catalysis to allostery to signal transduction.
openaire +1 more source
Coevolving residues distant from the ligand binding site are involved in GAF domain function
Communications ChemistryLigand binding to GAF domains regulates the activity of associated catalytic domains in various proteins, such as the cGMP-hydrolyzing catalytic domain of phosphodiesterase 5 (PDE5) activated by cGMP binding to GAFa domain. However, the specific residues
Wesam S. Ahmed +7 more
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Mechanisms for the Evolution of Protein Multimerization and Allostery [PDF]
Understanding how protein structure and function are determined by amino acid sequence is fundamental to biochemistry. Evolutionary biochemistry extends the classic sequence–structure–function paradigm by incorporating evolutionary history to understand ...
Cortez, Carlos
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eLife, 2017 We present in vivo single-cell FRET measurements in the Escherichia coli chemotaxis system that reveal pervasive signaling variability, both across cells in isogenic populations and within individual cells over time.
Johannes M Keegstra +5 more
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Coarse-grained model of entropic allostery [PDF]
, 2004 Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via
Rhoda J. Hawkins +3 more
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eLife, 2018 The structural interconversions that mediate the gene regulatory functions of RNA molecules may be different from classic models of allostery, but the relevant structural correlations have remained elusive in even intensively studied systems.
Siqi Tian, Wipapat Kladwang, Rhiju Das
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Mechanical Model of DNA Allostery
, 2015 The importance of allosteric effects in DNA is becoming increasingly appreciated, but the underlying mechanisms remain poorly understood. In this work, we propose a general modeling framework to study DNA allostery.
Tomáš Dršata (1342329) +5 more
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eLife, 2019 Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active states using cryo-electron microscopy. NO and the sGC-
Benjamin G Horst +6 more
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The Physical and Evolutionary Origins of Allostery [PDF]
Allostery is a fundamental property of proteins, describing the functional coupling between distantly separated sites within the molecule. In different manifestations, this property enables signal transduction, gene expression, and regulation.
Rouviere, Eric
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