Results 91 to 100 of about 10,740 (213)

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source

Approaches for studying allostery using network theory [PDF]

, 2019
Allostery is the process whereby binding of a substrate at a site other than the active site modulates the function of a protein. Allostery is thus one of the myriad of biological processes that keeps cells under tight regulatory control, specifically ...
Hodges, Maxwell
core   +1 more source

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 7, Page 1300-1311, July 2026.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Dielectric Allostery of Protein: Response of Myosin to ATP Binding

, 2016
Protein uses allostery to execute biological function. The physical mechanism underlying the allostery has long been studied, with the focus on the mechanical response by ligand binding.
Takato Sato (375462), Jun Ohnuki (3357470), Mitsunori Takano (555552)   +2 more
core   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 644-671, July/August 2026.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Structure-Based Statistical Mechanical Model Accounts for the Causality and Energetics of Allosteric Communication.

PLoS Computational Biology, 2016
Allostery is one of the pervasive mechanisms through which proteins in living systems carry out enzymatic activity, cell signaling, and metabolism control.
Enrico Guarnera, Igor N Berezovsky
doaj   +1 more source

Description of the rate‐limiting hydrogen tunneling mechanism for plant 9‐ and 13‐lipoxygenases

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Soybean lipoxygenase (GmLOX1), a plant 13‐LOX, has long been considered a model protein for non‐trivial, quantum hydrogen tunneling in enzyme catalysis. Hydrogen tunneling mechanisms have also been confirmed for LOXs across mammalian, fungal, and bacterial kingdoms.
Alex Kockler, Katherine Ray, Jordan King, Eric Anderson, Joi Walker, Nathaniel Gilbert, Patrick Horn, Adam R. Offenbacher   +7 more
wiley   +1 more source

Magnesium as a conformational gatekeeper of KRAS: Structural dynamics and therapeutic implications

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Magnesium serves as an essential cofactor for small GTPases, yet its structural role in regulating KRAS conformational dynamics and nucleotide exchange remains poorly understood. Here, we combine hydrogen–deuterium exchange mass spectrometry (HDX‐MS), native mass spectrometry, and functional assays to elucidate how Mg2+ stabilizes the KRAS ...
Bindu Y. Srinivasu, Tanvi S. Damerla, Alexander Stec, Zhiwei Zhou, John R. Engen, Kenneth D. Westover, Thomas E. Wales   +6 more
wiley   +1 more source

Role of mechanical allostery in kindlin-mediated integrin activation

Communications Physics
Kindlin proteins are central regulators of integrin-mediated cell adhesion, a process essential for various biological and pathological processes. Although structural studies have proposed that kindlins promote integrin activation and clustering via ...
Weiwei Zhang, Haibin Yang, Zihang Yang, Yunqiang Bian, Zhiyi Wei, Mingxi Yao, Jian Zhang, Wenfei Li, Cong Yu, Wei Wang   +9 more
doaj   +1 more source

Microbial Metabolite‐Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Bitter taste receptors (T2Rs) play an important role in physiological and cellular responses. Bitter tasting chemicals and microbial metabolites can bind to T2R14, which enables interactions between T2R14 and specific intracellular domains of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel.
Tejas Gupte, Nisha Singh, Vikram Bhatia, Kavisha Arora, Shayan Amiri, Paul Fernyhough, Anjaparavanda P. Naren, Shyamala Dakshinamurti, Prashen Chelikani   +8 more
wiley   +1 more source