Results 91 to 100 of about 18,856 (214)

Parsimonious evolutionary scenario for the origin of allostery and coevolution patterns in proteins

, 2019
Proteins display generic properties that are challenging to explain by direct selection, notably allostery, the capacity to be regulated through long-range effects, and evolvability, the capacity to adapt to new selective pressures.
Rivoire, Olivier
core   +1 more source

SegDesign: A modular framework for controllable protein segment engineering

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Local protein structure engineering, such as targeted remodeling of loops or flexible regions, is critical for mechanistic studies and protein optimization but remains challenging to perform in a controllable and reproducible manner. Despite advances in protein foundation models and generative structure design, most existing methods emphasize ...
Chenjie Feng, Junbo Yin, Chao Zha, Mohammed Saif, Xiaopeng Xu, Xin Gao, Wenjia He   +6 more
wiley   +1 more source

Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation

eLife, 2020
Inosine monophosphate dehydrogenase (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important roles in cellular proliferation and the immune response. IMPDH reversibly polymerizes in cells and tissues in response to
Matthew C Johnson, Justin M Kollman
doaj   +1 more source

Arabidopsis thaliana dehydroascorbate reductase 2 : conformational flexibility during catalysis [PDF]

, 2017
Dehydroascorbate reductase (DHAR) catalyzes the glutathione (GSH)-dependent reduction of dehydroascorbate and plays a direct role in regenerating ascorbic acid, an essential plant antioxidant vital for defense against oxidative stress.
Bodra, Nandita, De Proft, Frank, Huang, Jingjing, Messens, Joris, Pallo, Anna, Rosado, Leonardo Astolfi, Van Breusegem, Frank, Wahni, Khadija, Young, David   +8 more
core   +1 more source

Network medicine and systems pharmacology approaches to predicting adverse drug effects

British Journal of Pharmacology, Volume 183, Issue 8, Page 1627-1639, April 2026.
Identifying and understanding the relationships between drug intake and adverse effects that can occur due to inadvertent molecular interactions between drugs and targets is a difficult task, especially considering the numerous variables that can influence the onset of such events.
Alessio Funari, Giulia Fiscon, Paola Paci   +2 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, Volume 600, Issue 6, Page 847-861, March 2026.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Structure-Based Statistical Mechanical Model Accounts for the Causality and Energetics of Allosteric Communication.

PLoS Computational Biology, 2016
Allostery is one of the pervasive mechanisms through which proteins in living systems carry out enzymatic activity, cell signaling, and metabolism control.
Enrico Guarnera, Igor N Berezovsky
doaj   +1 more source

New Peptide-Based Pharmacophore Activates 20S Proteasome

Molecules, 2020
The proteasome is a pivotal element of controlled proteolysis, responsible for the catabolic arm of proteostasis. By inducing apoptosis, small molecule inhibitors of proteasome peptidolytic activities are successfully utilized in treatment of blood ...
Paweł A. Osmulski, Przemysław Karpowicz, Elżbieta Jankowska, Jonathan Bohmann, Andrew M. Pickering, Maria Gaczyńska   +5 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, Volume 600, Issue 6, Page 910-938, March 2026.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source