Results 91 to 100 of about 11,653 (194)
PLoS Computational Biology, 2016 Allostery is one of the pervasive mechanisms through which proteins in living systems carry out enzymatic activity, cell signaling, and metabolism control.
Enrico Guarnera, Igor N Berezovsky
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‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, Volume 600, Issue 18, Page 2686-2694, September 2026.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Emergence of Single- versus Multi-State Allostery [PDF]
Several physical mechanisms have been proposed to explain allostery in proteins. They differ by the number of internal states that they assume a protein to occupy, leaving open the question of what controls the emergence of these distinct physical forms ...
Rouviere, Eric +2 more
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Role of mechanical allostery in kindlin-mediated integrin activation
Communications PhysicsKindlin proteins are central regulators of integrin-mediated cell adhesion, a process essential for various biological and pathological processes. Although structural studies have proposed that kindlins promote integrin activation and clustering via ...
Weiwei Zhang +9 more
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On the emergence of single versus multi-state allostery
, 2022 Several physical mechanisms have been proposed to explain allostery in proteins. They differ by the number of internal states that they assume a protein to occupy, leaving open the question of what controls the emergence of these distinct physical forms ...
Rouviere, Eric +2 more
core +1 more source
Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
Nature Communications, 2016 Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically driven
Peter J. Watson +9 more
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Dielectric Allostery of Protein: Response of Myosin to ATP Binding
, 2016 Protein uses allostery to execute biological function. The physical mechanism underlying the allostery has long been studied, with the focus on the mechanical response by ligand binding.
Takato Sato (375462) +2 more
core +1 more source
Allosteric cross-talk in chromatin can mediate drug-drug synergy
Nature Communications, 2017 Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin ...
Zenita Adhireksan +7 more
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eLife, 2017 We present in vivo single-cell FRET measurements in the Escherichia coli chemotaxis system that reveal pervasive signaling variability, both across cells in isogenic populations and within individual cells over time.
Johannes M Keegstra +5 more
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Allostery in an Ensemble [PDF]
Biophysical Journal, 2011 Over the past 50 years of structural biology research, three incontrovertible, and as yet not fully reconciled, aspects of protein behavior have emerged: First, protein molecules manifest a broad range of seemingly complex functions, ranging from catalysis to allostery to signal transduction.
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