Results 101 to 110 of about 11,653 (194)

Allosteric mechanism of the V. vulnificus adenine riboswitch resolved by four-dimensional chemical mapping

eLife, 2018
The structural interconversions that mediate the gene regulatory functions of RNA molecules may be different from classic models of allostery, but the relevant structural correlations have remained elusive in even intensively studied systems.
Siqi Tian, Wipapat Kladwang, Rhiju Das
doaj   +1 more source

Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy

eLife, 2019
Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active states using cryo-electron microscopy. NO and the sGC-
Benjamin G Horst, Adam L Yokom, Daniel J Rosenberg, Kyle L Morris, Michal Hammel, James H Hurley, Michael A Marletta   +6 more
doaj   +1 more source

Amyloid-Driven Allostery

Biophysical Chemistry
The fields of allostery and amyloid-related pathologies, such as Parkinson's disease (PD), have been extensively explored individually, but less is known about how amyloids control allostery. Recent advancements have revealed that amyloids can drive allosteric effects in both intrinsically disordered proteins, such as alpha-synuclein (αS), and multi ...
Jaskiran, Garcha, Jinfeng, Huang, Karla, Martinez Pomier, Giuseppe, Melacini   +3 more
openaire   +2 more sources

Coevolving residues distant from the ligand binding site are involved in GAF domain function

Communications Chemistry
Ligand binding to GAF domains regulates the activity of associated catalytic domains in various proteins, such as the cGMP-hydrolyzing catalytic domain of phosphodiesterase 5 (PDE5) activated by cGMP binding to GAFa domain. However, the specific residues
Wesam S. Ahmed, Anupriya M. Geethakumari, Asfia Sultana, Anmol Tiwari, Tausif Altamash, Najla Arshad, Sandhya S. Visweswariah, Kabir H. Biswas   +7 more
doaj   +1 more source

DEVELOPMENT OF NOVEL COMPUTATIONAL METHODS FOR CHARACTERIZING PROTEIN ALLOSTERY [PDF]

Many proteins cannot be adequately understood and drugged without considering allostery. Yet allostery is often difficult to study. Proteins of interest to me, such as the SARS-CoV-2 main protease, have remained poorly understood despite extensive ...
Evans, Daniel James
core   +1 more source

Correlated Motions and Allostery [PDF]

, 2011
Allostery describes altered protein function at one site due to a perturbation at another site. One mechanism of allostery involves correlated motions, which can occur even in the absence of substantial conformational change.
McClendon, Christopher
core  

Mechanisms for the Evolution of Protein Multimerization and Allostery [PDF]

Understanding how protein structure and function are determined by amino acid sequence is fundamental to biochemistry. Evolutionary biochemistry extends the classic sequence–structure–function paradigm by incorporating evolutionary history to understand ...
Cortez, Carlos
core   +1 more source

A Unified View of Allostery

Allostery is a fundamental property of proteins that represents the functional coupling between distantly located sites. In different manifestations, this property underlies signal transduction, gene expression, and regulation -- elementary reactions in ...
Rouviere, Eric, Ranganathan, Rama, Rivoire, Olivier   +2 more
core  

Evolution of allostery in isocitrate lyase

Allostery is crucial for regulating the activity of enzymes in many biochemical and physiological processes. In allostery, the binding of ligands in one site of a protein changes the binding or activity of another site on the protein.
Guo, Shuning
core  

The Allosteric Revolution: From Static Structures to Conformational Ensembles and Next-Generation Therapeutics. [PDF]

J Mol Biol
Nussinov R, Jang H.
europepmc   +1 more source