Results 81 to 90 of about 18,856 (214)

Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Cofactors [PDF]

, 2019
Transition-metal catalysis is a powerful tool for the construction of chemical bonds. Here we show that a non-heme iron enzyme can catalyze olefin aziridination and nitrene C–H insertion, and that these activities can be improved by directed evolution ...
Arnold, Frances H., Goldberg, Nathaniel, Knight, Anders M., Zhang, Ruijie   +3 more
core   +1 more source

The atomic structure of human dystrophin spectrin‐like repeat 24

Acta Crystallographica Section F, Volume 82, Issue 5, Page 184-193, May 2026.
The atomic structure of human dystrophin spectrin‐like repeat 24 was determined at 2.14 Å resolution.The structure of spectrin‐like repeat 24 of human dystrophin was determined at 2.5 Å effective resolution. The structure exhibits a three‐helix bundle fold, common to all spectrin‐repeat family members, and shares a high degree of homology with existing
Oakley Streeter, Ke Shi, Hannah Bui, Hideki Aihara, James M. Ervasti, Robert Evans III, Joseph M. Muretta   +6 more
wiley   +1 more source

Amyloid-Driven Allostery

Biophysical Chemistry
The fields of allostery and amyloid-related pathologies, such as Parkinson's disease (PD), have been extensively explored individually, but less is known about how amyloids control allostery. Recent advancements have revealed that amyloids can drive allosteric effects in both intrinsically disordered proteins, such as alpha-synuclein (αS), and multi ...
Jaskiran, Garcha, Jinfeng, Huang, Karla, Martinez Pomier, Giuseppe, Melacini   +3 more
openaire   +2 more sources

Convergent Allostery in Ribonucleotide Reductase [PDF]

Nature Communications, 2018
AbstractRibonucleotide reductases (RNRs) use a conserved radical-based mechanism to catalyze the conversion of ribonucleotides to deoxyribonucleotides. Within the RNR family, class Ib RNRs are notable for being largely restricted to bacteria, including many pathogens, and for lacking an evolutionarily mobile ATP-cone domain that allosterically controls
William C. Thomas, F. Phil Brooks, Audrey A. Burnim, John-Paul Bacik, JoAnne Stubbe, Jason T. Kaelber, James Z. Chen, Nozomi Ando   +7 more
openaire   +3 more sources

Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket.

PLoS ONE, 2013
HtrA2, a trimeric proapoptotic serine protease is involved in several diseases including cancer and neurodegenerative disorders. Its unique ability to mediate apoptosis via multiple pathways makes it an important therapeutic target.
Pruthvi Raj Bejugam, Raja R Kuppili, Nitu Singh, Nikhil Gadewal, Lalith K Chaganti, G Madhavi Sastry, Kakoli Bose   +6 more
doaj   +1 more source

Hydrogen bonds and asymmetrical heat diffusion in a-Helices. A Computational Analysis

, 2015
In this work, we report the heat rectifying capability of a-helices. Using molecular dynamics simulations we show an increased thermal diffusivity in the C-Terminal to N-Terminal direction of propagation.
Gutierrez, Gonzalo, Miño-Galaz, German A.   +1 more
core   +2 more sources

Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations. [PDF]

, 2018
Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their mechanisms are poorly understood. Here, 19F NMR is used to delineate the effects of cations on functional states of the adenosine A2A GPCR.
Ernst, Oliver P, García, Angel E, Larda, Sacha T, Lyda, Brent, Neale, Chris, Pichugin, Dmitry, Pomès, Régis, Prosser, R Scott, Sljoka, Adnan, Sunahara, Roger K, Tsuchimura, Nobuyuki, Ye, Libin   +11 more
core   +2 more sources

A parameterized two-domain thermodynamic model explains diverse mutational effects on protein allostery

eLife
New experimental findings continue to challenge our understanding of protein allostery. Recent deep mutational scanning study showed that allosteric hotspots in the tetracycline repressor (TetR) and its homologous transcriptional factors are broadly ...
Zhuang Liu, Thomas G Gillis, Srivatsan Raman, Qiang Cui   +3 more
doaj   +1 more source

Prediction of Functional Sites in SCOP Domains using Dynamics Perturbation Analysis [PDF]

, 2008
Dynamics perturbation analysis (DPA) finds regions in a protein structure where proteins are "ticklish", i.e., where interactions cause a large change in protein dynamics.
Dengming Ming, Judith D. Cohn, Michael E. Wall   +2 more
core   +2 more sources

Hydroxyl radical footprinting modification reveals an intradomain communication pathway in EFL1 disrupted by a Shwachman‐Diamond syndrome‐associated mutation

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Shwachman‐Diamond syndrome (SDS) is a rare genetic disorder characterized by pancreatic insufficiency and neutropenia. While most cases are linked to mutations in the SBDS gene, some involve mutations in the GTPase EFL1. This protein works with SBDS to release the anti‐association factor eIF6 from the 60S ribosomal subunit during ribosome ...
Jonathan A. Zúñiga‐Domínguez, Rohit Jain, Martín González‐Andrade, Erik R. Farquhar, Mark R. Chance, Abril Gijsbers, Nuria Sánchez‐Puig   +6 more
wiley   +1 more source