Results 81 to 90 of about 18,737 (212)
Detecting Repetitions and Periodicities in Proteins by Tiling the Structural Space [PDF]
, 2013 The notion of energy landscapes provides conceptual tools for understanding the complexities of protein folding and function. Energy Landscape Theory indicates that it is much easier to find sequences that satisfy the "Principle of Minimal Frustration ...
Espada, Rocío +4 more
core +2 more sources
Understanding how enzymes work: the journey to ensemble–function studies
The FEBS Journal, EarlyView.For decades, structure–function has dominated biochemistry. Structures are highly valuable, yet more is needed to achieve a quantitative understanding of biomolecular function, because function emerges from an ensemble of states, rather than a static structure. We describe an ensemble–function framework applied to quantitatively dissect serine protease
Daniel Herschlag, Siyuan Du
wiley +1 more source
PLoS Computational Biology, 2018 Intrinsically disordered proteins/regions (IDPs/IDRs) are prevalent in allosteric regulation. It was previously thought that intrinsic disorder is favorable for maximizing the allosteric coupling.
Luhao Zhang, Maodong Li, Zhirong Liu
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi +11 more
wiley +1 more source
, 2008 Citation: 'allostery' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.A00241 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +2 more sources
Allosteric Conversation in the Androgen Receptor Ligand-Binding Domain Surfaces [PDF]
, 2012 Androgen receptor (AR) is a major therapeutic target that plays pivotal roles in prostate cancer (PCa) and androgen insensitivity syndromes. Wepreviously proposed that compounds recruited to ligand-binding domain (LBD) surfaces could regulate AR activity
Baxter, John D +9 more
core +2 more sources
Mechanisms of DNA-Mediated Allostery
Physical Review Letters, 2023 Proteins often regulate their activities via allostery - or action at a distance - in which the binding of a ligand at one binding site influences the affinity for another ligand at a distal site. Although less studied than in proteins, allosteric effects have been observed in experiments with DNA as well. In these experiments two or more proteins bind
Segers, Midas +3 more
openaire +4 more sources
Protein Science, Volume 35, Issue 4, April 2026.Abstract Shwachman‐Diamond syndrome (SDS) is a rare genetic disorder characterized by pancreatic insufficiency and neutropenia. While most cases are linked to mutations in the SBDS gene, some involve mutations in the GTPase EFL1. This protein works with SBDS to release the anti‐association factor eIF6 from the 60S ribosomal subunit during ribosome ...
Jonathan A. Zúñiga‐Domínguez +6 more
wiley +1 more source
PLoS Computational Biology, 2014 Complex networks of interacting residues and microdomains in the structures of biomolecular systems underlie the reliable propagation of information from an input signal, such as the concentration of a ligand, to sites that generate the appropriate ...
Michael V LeVine, Harel Weinstein
doaj +1 more source
Evolution of sparsity and modularity in a model of protein allostery
, 2014 The sequence of a protein is not only constrained by its physical and biochemical properties under current selection, but also by features of its past evolutionary history.
Hemery, Mathieu, Rivoire, Olivier
core +3 more sources