Results 171 to 180 of about 15,644 (230)

Inhibition of Urease by Alloxan and Alloxanic Acid

Nature, 1959
EVER since the discovery that alloxan could induce diabetes1 in animals, this compound has been the agent of choice in producing experimental diabetes. While the maximal modifications in the chemical structure of alloxan compatible with maintenance of diabetogenic action are known, its mode of action is still debated.
C T, GRAY, M S, BROOKE, J C, GERHART
openaire   +2 more sources

Effect of alloxan on permeability of pancreatic islet tissue in vitro

American Journal of Physiology, 1964
The effect of alloxan on the permeability of toadfish islet slices was studied in vitro at 0 C, pH 7.0. When islet slices were incubated in d-mannitol-1-C14, a compound which does not enter cells, the C14 content of the slice reached 30% of that of the ...
S J Cooperstein, Arnold Lazarow, D Watkins   +2 more
exaly   +2 more sources

The effect of alloxan, and alloxan‐induced diabetes on the kidney

The Anatomical Record, 1984
AbstractAlloxan is known to induce diabetic renal changes as well as causing nephrotoxic alterations. However, no ultrastructural study has been performed to differentiate diabetic verses toxic affects of alloxan to the tubule and/or glomerulus. Therefore the present study used the “protected” kidney model to prevent one kidney from being exposed to ...
A P, Evan, S A, Mong, B A, Connors, G R, Aronoff, F C, Luft   +4 more
openaire   +2 more sources

Metal Chelates of Alloxan*

Journal of the American Pharmaceutical Association (Scientific ed.), 1956
Abstract Alloxan has been found to undergo chelation with Co + + , Ni ++ , and Cu ++ ions in aqueous solution, giving products having a 1:1 ratio of metal to alloxan.The isolated chelates were found to elicit an increase in blood sugar in rabbits comparable to that from alloxan itself, but over a much longer period of time.Metal chelates of two ...
W O, FOYE, W E, LANGE
openaire   +2 more sources

Protective mechanism of glucose against alloxan-induced β-cell damage: pivotal role of ATP

Experimental and Molecular Medicine, 2000
Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian hamster transformed beta-cell line. Alloxan
Hye-Won Rho, Hyung-Rho Kim, H R Kim
exaly   +2 more sources

A RAMAN Spectroscopic Investigation of Alloxan and Alloxan Monohydrate

Spectroscopy Letters, 1991
Abstract The present Raman investigation of anhydrous alloxan and the misnamed alloxan monohydrate suggests that some of the assignments previously made on basis of the IR spectrum of the anhydrous compound must be changed, i.e., the ones related to the NH stretching and ring breathing modes. The hydrogen bonding network in the crystal of the so called
L. F. C. de Oliveira, P. S. Santos
openaire   +1 more source

Alloxan therapy for nesidioblastosis

Journal of Pediatric Surgery, 1984
Two patients with nesidioblastosis presented to the Royal Hospital for Sick Children in Glasgow and developed recurrent hypoglycemia after subtotal pancreatectomy. They were treated successfully with alloxan (mesoxalyl urea). Alloxan is recommended as an alternative to further radical surgery.
P M, Davidson, D G, Young, R W, Logan, S, Lockhart, W J, Patrick   +4 more
openaire   +2 more sources

Alloxan Diabetes in a Ruminant

Nature, 1946
IN the ruminant, the digestion of cellulose and other related carbohydrates is achieved through the conversion by the symbiotic flora of the paunch to simple fatty acids with the evolution of methane and carbon dioxide. If the fatty acids which are absorbed constitute the animal's main source of energy, it is possible that ruminants have a novel ...
openaire   +2 more sources