Results 71 to 80 of about 2,036,091 (286)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

ContinuITy-Project/ContinuITy: Release at project end (v2.9.346)

open access: yes, 2020
ContinuITy is a research project on "Automated Performance Testing in Continuous Software Engineering", launched by Novatec Consulting GmbH and the University of Stuttgart (Software Quality and Architecture Group).
Tobias Angerstein   +3 more
core   +1 more source

Comparable Almost Continuous Functions

open access: yesReal Analysis Exchange, 2003
The author defines three conditions for families of real valued functions. The first one characterizes those families \(\mathcal F\) of size \(\leq\) continuum for which there is a positive function \(g\) such that \(f+g\) is almost continuous in the sense of Stallings. The second one describes the same property for families \(\mathcal F\) of size less
openaire   +3 more sources

Almost e∗ -continuous functions and their characterizations

open access: yesJournal of Nonlinear Sciences and Applications, 2016
WOS ...
Ayhan, B.S., Özkoç, M.
openaire   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Maximums of Almost Continuous Functions

open access: yesReal Analysis Exchange, 2005
It is shown that each function which can be written as the maximum of two Darboux functions can be written as the maximum of two almost continuous functions as well.
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

On some properties of the spaces of almost continuous functions

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1996
In this paper we prove that, in the space 𝒜 of almost continuous functions (with the metric of uniform convergence), the set of functions of the first class of Baire is superporous at each point of this ...
Ryszard Jerzy Pawlak
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

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