Results 101 to 110 of about 2,655,457 (316)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Polymorphism and association analysis of a drought-resistant gene TaLTP-s in wheat

open access: yesJournal of Integrative Agriculture, 2016
Lipid transfer protein (LTP) is a kind of small molecular protein, which is named for its ability to transfer lipid between cell membranes. It has been proved that the protein is involved in the responding to abiotic stresses.
Qian LI   +5 more
doaj   +1 more source

Encodings and models for antimicrobial peptide classification for multi-resistant pathogens

open access: yesBioData Mining, 2019
Antimicrobial peptides (AMPs) are part of the inherent immune system. In fact, they occur in almost all organisms including, e.g., plants, animals, and humans.
S. Spänig, D. Heider
semanticscholar   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Changing gender relations, declining fertility? An analysis of childbearing trajectories in 19th-century Netherlands

open access: yesDemographic Research, 2019
Background: A long-standing and still unresolved debate has developed on whether the historical fertility transition was caused by 'spacing' (increasing the time between births) or by stopping (terminating childbearing at younger ages).
Hilde Bras, Reto Schumacher
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Nuclear dimension and Z-stability of pure C*-algebras [PDF]

open access: yes, 2011
In this article I study a number of topological and algebraic dimension type properties of simple C*-algebras and their interplay. In particular, a simple C*-algebra is defined to be (tracially) (m,\bar{m})-pure, if it has (strong tracial) m-comparison ...
In Erinnerung An Meinen Vater   +1 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

An almost sure conditional convergence result and an application to a generalized Polya urn [PDF]

open access: yes, 2009
We prove an almost sure conditional convergence result toward a Gaussian kernel and we apply it to a two-colors randomly reinforced ...
Crimaldi, Irene
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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