Results 131 to 140 of about 4,545,606 (290)

The connectivity degree controls the difficulty in reservoir design of random boolean networks

Frontiers in Computational Neuroscience
Reservoir Computing (RC) is a paradigm in artificial intelligence where a recurrent neural network (RNN) is used to process temporal data, leveraging the inherent dynamical properties of the reservoir to perform complex computations.
Emmanuel Calvet, Bertrand Reulet, Jean Rouat   +2 more
doaj   +1 more source

Alcohol/Leisure Complementarity: Empirical Estimates and Implications for Tax Policy [PDF]

This paper provides a first attempt to estimate the cross-price elasticity between alcoholic beverages and leisure, which is critical for assessing how much alcohol taxation might be warranted on fiscal grounds.
Parry, Ian W.H., West, Sarah E.
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Almost Optimal PAC Learning for 𝑘-Means

Proceedings of the 57th Annual ACM Symposium on Theory of Computing
Given a set of points, the k-means clustering problem consists of finding a partition of a set of points into k clusters such that the sum of squared Euclidean distances between the points and their assigned centers is minimized. In this paper, we consider learning bounds for this problem.
Vincent Cohen-Addad, Silvio Lattanzi, Chris Schwiegelshohn   +2 more
openaire   +1 more source

The Complexity of Almost-Optimal Coordination

, 1993
The problem of fault-tolerant coordination is fundamental in distributed computing. In the past, researchers have considered the complexity of achieving optimal simultaneous coordination under various failure assumptions.
Rida A. Bazzi, Gil Neiger
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

THE ALMOST IDEAL SUPPLY SYSTEM AND AGRICULTURAL PRODUCTION IN THE UNITED STATES [PDF]

This paper estimates an Almost Ideal Supply System using aggregate U.S. agricultural data. Share equations derived from an indirect production function yield elasticities that are consistent with production theory.
Hilmer, Christiana E., Holt, Matthew T.
core  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source