Results 91 to 100 of about 554,389 (270)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Almost Periodic Solutions of Differential Equations with Generalized Piecewise Constant Delay

Mathematics
In this paper, we investigate differential equations with generalized piecewise constant delay, DEGPCD in short, and establish the existence and stability of a unique almost periodic solution that is exponentially stable.
Kuo-Shou Chiu
doaj   +1 more source

δ-Almost Periodic Functions and Applications to Dynamic Equations

Mathematics, 2019
In this paper, by employing matched spaces for time scales, we introduce a δ -almost periodic function and obtain some related properties. Also the hull equation for homogeneous dynamic equation is introduced and results of the existence are ...
Chao Wang, Ravi P. Agarwal, Donal O’Regan   +2 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Almost periodic and quasi-periodic functions. A brief survey and some applications [PDF]

Surveys in Mathematics and its Applications
In the present work, we study almost-periodic and quasi-periodic functions, their main properties and some related results. We also present almost periodic functions with parameters, which we adapt to the quasi-periodic framework. We then show that these
Dhaou Lassoued
doaj  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Almost Periodic Solutions for Some Convolution Equations

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2013
We use the theory of Fourier series for almost periodic functions to looking for complex-valued functions f which are almost periodic on R and satisfy the following ...
Corduneanu Silvia-Otilia
doaj   +1 more source

Almost Periodic Solutions on a Class Secondorder Differential Equations with Piecewise Constant Argument

Journal of Harbin University of Science and Technology, 2019
Almost periodic solutions of differential equations are more general than periodic solutions, so almost periodic solutions will be studied on a class secondorder differential equations with piecewise constant argument.
YAO Hui-li, ZHANG Yue-jiao, HOU Sheng-nan   +2 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Weighted Pseudo Almost-Periodic Functions and Applications to Semilinear Evolution Equations

Abstract and Applied Analysis, 2012
We first give a solution to a key problem concerning the completeness of the space of weighted pseudo almost-periodic functions and then establish a new composition theorem with respect to these functions.
Jun Zhang, Ti-Jun Xiao, Jin Liang
doaj   +1 more source