Results 101 to 110 of about 554,389 (270)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Asymptotic Almost Periodic Functions with Range in a Topological Vector Space

open access: yesJournal of Function Spaces and Applications, 2013
The notion of asymptotic almost periodicity was …first introduced by Fréchet in 1941 in the case of …finite dimensional range spaces. Later, its extension to the case of Banach range spaces and locally convex range spaces has been considered by several ...
Liaqat Ali Khan, Saud M. Alsulami
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Generalized Almost Periodicity in Measure

open access: yesMathematics
This paper investigates diverse classes of multidimensional Weyl and Doss ρ-almost periodic functions in a general measure setting. This study establishes the fundamental structural properties of these generalized ρ-almost periodic functions, extending ...
Marko Kostić   +3 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Almost periodic generalized functions

open access: yes, 2011
The aim of this paper is to introduce and to study an algebra of almost periodic generalized functions containing the classical Bohr almost periodic functions as well as almost periodic Schwartz ...
Bouzar, Chikh, Khalladi, Mohamed Taha
openaire   +3 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

INCLUSION RELATIONS CONCERNING WEAKLY ALMOST PERIODIC FUNCTIONS AND FUNCTIONS VANISHING AT INFINITY [PDF]

open access: yesJournal of Sciences, Islamic Republic of Iran, 1995
We consider the space of weakly almost periodic functions on a transformation semigroup (S, X , ?) and show that if X is a locally compact noncompact uniform space, and ?
doaj  

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