Results 81 to 90 of about 3,398,742 (244)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Electronic Journal of Differential Equations, 2016 We study weighted pseudo almost automorphic solutions for the nonlinear fractional difference equation $$ \Delta^{\alpha}u(n)=Au(n+1)+f(n, u(n)),\quad n\in \mathbb{Z}, $$ for ...
Edgardo Alvarez, Carlos Lizama
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Mental Health, 2020 Introduction According to modern scholars (N. Maslova, B. Astafiev), one of the important reasons for the global planetary crisis, including modern educational system in particular, is violation of the conformity of nature principles in the process of ...
Tamara Tyurina, Sofiya Stavkova
doaj +1 more source
Almost maximally almost-periodic group topologies determined by T-sequences
Topology and its Applications, 2006 A sequence $\{a_n\}$ in a group $G$ is a {\em $T$-sequence} if there is a Hausdorff group topology $τ$ on $G$ such that $a_n\stackrelτ\longrightarrow 0$. In this paper, we provide several sufficient conditions for a sequence in an abelian group to be a $T$-sequence, and investigate special sequences in the Prüfer groups $\mathbb{Z}(p^\infty)$.
openaire +3 more sources
Computation of H-infinity norm of linear discrete-time periodic systems [PDF]
, 2006 We propose an efficient an numerically reliable procedure for the computation of H-infinity norm of discrete-time linear periodic systems. The new procedure is general being applicable to both standard as well as descriptor periodic systems with time ...
Varga, Andreas
core
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Perfect Gaussian Integer Sequences With Two Cycles
IEEE AccessThe complex sequences including Gaussian integers have received considerable attention in the past due to their wide applications in communications and cryptosystems. This paper proposes three new base sequences along with six known ones to construct two
Kun-Lin Lee, Chong-Dao Lee, Yan-Haw Chen
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source