Results 71 to 80 of about 3,398,742 (244)
Controls of nucleosome positioning in the human genome.
PLoS Genetics, 2012 Nucleosomes are important for gene regulation because their arrangement on the genome can control which proteins bind to DNA. Currently, few human nucleosomes are thought to be consistently positioned across cells; however, this has been difficult to ...
Daniel J Gaffney +8 more
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Computational Methods for Periodic Systems - An Overview [PDF]
, 2001 We present an up-to-date survey of numerical methods for the analysis and design of linear discrete-time periodic systems. The basic tool is the periodic Schur form and its variants, for which a certain form of numerical stability can be ...
IFAC Workshop on Periodic Control Systems (PSYCO 2001) +3 more
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Practical early stopping for adaptive barrier SGD: balancing stochastic speed with validation accuracy [PDF]
Iranian Journal of Numerical Analysis and OptimizationStochastic Gradient Descent (SGD) algorithms based on adaptive barrier functions are highly efficient for large-scale constrained optimization. However, their inherent stochastic nature leads to the critical ”last- iterate problem”, where update noise ...
Abdelouakil Fillali +2 more
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
MODELING HEAT EXCHANGE DEPENDING ON THE PRANDTL NUMBER FOR VARIOUS GEOMETRIC AND REGIME PARAMETERS
Вестник Дагестанского государственного технического университета: Технические науки, 2020 Objectives. The aim is to study the dependency of the distribution of integral heat transfer during turbulent convective heat transfer in a pipe with a sequence of periodic protrusions of semicircular geometry on the Prandtl number using the calculation ...
I. E. Lobanov
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Almost Periodic and Asymptotically Almost Periodic Solutions of Liénard Equations [PDF]
, 2011 The aim of this paper is to study the almost periodic and asymptotically almost periodic solutions on (0,+1) of the Li´enard equation x′′ + f(x)x′ + g(x) = F(t), where F : T !
null null +4 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Psychoacoustic Properties of Fibonacci Sequences
Acta Polytechnica, 2008 1202, Fibonacci set up one of the most interesting sequences in number theory. This sequence can be represented by so-called Fibonacci Numbers, and by a binary sequence of zeros and ones.
J. Sokoll, S. Fingerhuth
doaj