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Aloe-emodin-induced apoptosis in human gastric carcinoma cells

Food and Chemical Toxicology, 2007
The purpose of this study was to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two distinct human gastric carcinoma cell lines, AGS and NCI-N87. We demonstrate that aloe-emodin induced cell death in a dose- and time-dependent manner.
Sheng-Hsuan, Chen   +4 more
openaire   +4 more sources

Antagonism of androgen receptor signaling by aloe-emodin

Food and Chemical Toxicology, 2023
Over the past decades, androgen receptor (AR) signaling has been a key driver of both primary and recurrent prostate cancer. In this work, aloe-emodin was identified as a novel AR antagonist, effectively inhibiting AR signaling. Firstly, aloe-emodin can inhibit LNCaP cell growth by promoting apoptosis. Then, the results of Western blot and quantitative
Jingqi, Zhao   +4 more
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The isomers, aloe-emodin and emodin, possess differential inhibitory activities against CYP1B1 enzyme

Steroids, 2022
Aloe-emodin, known as a 3-hydroxymethyl-chrysazin, is one of anthraquinones mainly found in Rheum officinale Baill, Rheum palmatum L and Rheum tanguticum Maxim. Ex BALF. In recent studies, aloe-emodin possesses many pharmacological effects, including antitumor, antibacterial, antiviral, anti-inflammatory, cardiovascular protection, liver protection ...
Xin, Meng   +4 more
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Inhibition of CYP3A4 enhances aloe-emodin induced hepatocyte injury

Toxicology in Vitro, 2022
Aloe-emodin (AE) is a natural hydroxyanthraquinone derivative that was found in many medicinal plants and ethnic medicines. AE showed a wide array of pharmacological activities including anticancer, antifungal, laxative, antiviral, and antibacterial effects. However, increasing number of published studies have shown that AE may have some hepatotoxicity
Ying-Huan, Hu   +4 more
openaire   +2 more sources

Photochemistry and Phototoxicity of Aloe Emodin¶

Photochemistry and Photobiology, 2002
Photochemical pathways leading to the phototoxicity of the aloe vera constituent aloe emodin were studied. The results indicate a photochemical mechanism involving singlet oxygen to be the most likely pathway responsible for the observed phototoxicity. Aloe emodin was found to efficiently generate singlet oxygen when irradiated with UV light (phidelta =
Peter, Vath   +2 more
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Modification of emodin and aloe-emodin by glycosylation in engineered Escherihia coli

World Journal of Microbiology and Biotechnology, 2015
Glycosyltransferase from Bacillus licheniformis DSM13 (YjiC) was used for enzymatic modification of emodin and aloe-emodin in vitro and in vivo. In order to increase the availability of UDP-glucose, three genes involved in the production of precursors of NDP-sugar in Escherichia coli BL21 (DE3) viz.
Gopal Prasad, Ghimire   +4 more
openaire   +2 more sources

Einfache Synthese des (?+)-6-Desoxycarminomycinons aus Aloe-Emodin

Angewandte Chemie International Edition in English, 1983
AbstractDas vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1983, 1267.
Karsten Krohn, Burkhard Sarstedt
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Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review

The American Journal of Chinese Medicine, 2014
Aloe-emodin (AE), a bioactive anthraquinone derived from both Aloe vera and Rheum officinale, has recently been demonstrated to have various pharmacological activities. With the widespread popularity of natural products, such as antineoplastic drugs, AE has attracted much attention due to its remarkable antineoplastic activity on multiple tumor cells ...
Ruie, Chen   +5 more
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