Results 211 to 220 of about 6,403 (242)
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Aloe-emodin alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis
Free Radical Biology and Medicine, 2023Aloe-emodin (AE), a novel ferroptosis inhibitor, alleviates the doxorubicin (DOX)-induced cardiotoxicity in H9c2 rat cardiomyocytes. The inhibition of ferroptosis and the protective effect against cardiotoxicity were evaluated via MTT assay in H9c2 cells.
Ying He +4 more
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Evaluation of the anti-angiogenic effect of aloe-emodin
Cellular and Molecular Life Sciences, 2006The present study identified aloe-emodin (AE, a hydroxyanthraquinone from Aloe vera and other plants) as a new anti-angiogenic compound with inhibitory effects in an in vivo angiogenesis assay and evaluates its effects on specific key steps of the angiogenic process.
C, Cárdenas, A R, Quesada, M A, Medina
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Remote Loading of Aloe Emodin in Gemini-Based Cationic Liposomes
Langmuir, 2014Anthraquinone compound aloe-emodin (AE) has shown antineoplastic, antibacterial, antiviral, and anti-inflammatory properties and scavenging activity on free radicals. Because of these therapeutic features, AE has been attracting increasing interest and could be applied in the curing of many diseases.
Chiara Giuliani +5 more
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Aloe emodin inhibits the cytotoxic action of tumor necrosis factor
European Journal of Pharmacology, 2007We demonstrate the capacity of an herbal anthraquinone aloe emodin to reduce the cytotoxicity of the proinflammatory cytokine tumor necrosis factor (TNF) towards L929 mouse fibrosarcoma and U251 human glioma cell lines. Aloe emodin inhibited both TNF-induced cell necrosis and apoptosis, but it did not reduce cell death induced by UV radiation or ...
Harhaji-Trajković, Ljubica +6 more
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Toxicology Mechanisms and Methods, 2004
The interaction of the dihydroxyanthraquinones, emodin (1), aloe-emodin (2), and rhein (3) with human serum albumin (HSA) has been studied through fluorescence spectroscopy. Quenching studies and the association constant of the anthraquinoid compounds 1, 2, and 3 in the presence of HSA were estimated. The binding and quenching studies suggest that only
F, Vargas, C, Rivas, M, Medrano
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The interaction of the dihydroxyanthraquinones, emodin (1), aloe-emodin (2), and rhein (3) with human serum albumin (HSA) has been studied through fluorescence spectroscopy. Quenching studies and the association constant of the anthraquinoid compounds 1, 2, and 3 in the presence of HSA were estimated. The binding and quenching studies suggest that only
F, Vargas, C, Rivas, M, Medrano
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Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin
Cellular and Molecular Life Sciences, 2005The present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum(II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines. The protective effect of AE was demonstrated by MTT and crystal violet assays for cell viability, and involved supression ...
Mijatović, Sanja +6 more
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Rhein and Aloe-Emodin Kinetics from Senna Laxatives in Man
Pharmacology, 1993Therapeutic doses of two laxatives (Agiolax and Sennatin) were repeatedly administered to 10 healthy volunteers in a two-way change-over design. Blood samples were collected up to 96 h after the first dose, and plasma levels of total aloe-emodin and rhein were determined simultaneously with a sensitive (lower limit of quantification: 0.5 ng aloe-emodin
G, Krumbiegel, H U, Schulz
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Cell-type dependent response of melanoma cells to aloe emodin
Food and Chemical Toxicology, 2012Intrinsic characteristics of melanoma cells such as expression of inducible nitric oxide synthase (iNOS), redox status, and activity of signaling pathways involved in proliferation, differentiation and cell death define the response of the cells to the diverse treatments.
Radović, Julijana M +8 more
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Synthesis and Antitumor Activity of Natural Compound Aloe Emodin Derivatives
Chemical Biology & Drug Design, 2014In this study, we have synthesized novel water soluble derivatives of natural compound aloe emodin 4(a–j) by coupling with various amino acid esters and substituted aromatic amines, in an attempt to improve the anticancer activity and to explore the structure–activity relationships.
Naraganahalli R, Thimmegowda +13 more
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Photodynamic Inactivation of Staphylococcus aureus Using Aloe-emodin as Photosensitizer
Food Research InternationalAloe-emodin (AE) is a natural compound with photodynamic properties. The aim of this study was to investigate the inhibitory effect of AE-mediated photodynamic inactivation (PDI) on Staphylococcus aureus (S. aureus). The bacteriostatic efficiency under different photodynamic conditions and photosensitizing mechanism was studied in detail.
Jiali Wu +4 more
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