Results 71 to 80 of about 107,949,779 (166)

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Distinct Microbial and Host Proteome Signatures Relate to Proteolytic Activity in Gingival Crevicular Fluid in an Exploratory Study of Patients With Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim Risk assessment tools for periodontitis lack sufficient precision to predict disease progression. The aim of this exploratory study was to evaluate proteolytic activity (PA) in gingival crevicular fluid in relation to clinically assessed progression risk, microbial community composition and host proteome. Materials and Methods Samples were
Miguel Carda‐Diéguez, Stefan Rüdiger, Gunnel Svensäter, Henrik Jansson, Tirthankar Mohanty, Yashuan Chao, Christofer Karlsson, Johan Malmström, Oonagh Shannon, Álex Mira, Julia R. Davies   +10 more
wiley   +1 more source

Alcohol‐Associated Pancreatitis Confers Higher Risk of Advanced Liver Disease Than Alcohol Withdrawal Syndrome

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Alcohol‐associated liver disease frequently presents late as decompensated cirrhosis, representing a missed opportunity for intervention. Extrahepatic alcohol‐related presentations requiring acute care, such as alcohol‐associated pancreatitis and alcohol withdrawal syndrome, may identify heavy drinkers at varying risk for ...
Butros Fakhoury, Leandro Sierra, Krishan Patel, Hyundam Gu, Luis Antonio Díaz, Juan Pablo Arab   +5 more
wiley   +1 more source

Beyond biologic sex: Exploratory insights into the heterogeneity of hormonal and contextual drivers of periodontal and peri‐implant outcomes

Periodontology 2000, EarlyView.
Abstract Background Periodontal and peri‐implant diseases are multifactorial inflammatory conditions influenced by microbial, host, hormonal, genetic, and behavioral factors. Although sex‐based differences in immune and inflammatory responses are well recognized in medicine, the extent to which biologic sex and hormonal status influence the prevalence,
Caitlin Neapole, Mark Gettas, Roberto Farina, Yvonne Hernandez‐Kapila   +3 more
wiley   +1 more source

[Alpha 1-antitrypsin deficiency].

Revue des maladies respiratoires, 2016
Pulmonary emphysema and liver disease are the clinical expressions of alpha 1-antitrypsin deficiency, an autosomal recessive genetic disease.Alpha 1-antitrypsin deficiency is usually associated with the homozygous Z variant of the SERPINA1 gene.
openaire   +3 more sources

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Strategies for Mitigating Anti‐Nutritional Factors in Legumes: A Review of Traditional and Innovative Processing Techniques for Enhanced Bioavailability

Legume Science, Volume 8, Issue 4, December 2026.
ABSTRACT Legumes (family Fabaceae) are vital, nutrient‐dense global resources rich in proteins, complex carbohydrates and micronutrients. Although offering agronomic benefits like nitrogen fixation, their dietary utilization is often constrained by anti‐nutritional factors (ANFs) such as phytates, tannins, lectins and oligosaccharides, which reduce ...
Diana Kavaya, Muhammad Siddiq, Leonard M. P. Rweyemamu, Lilian Daniel Kaale   +3 more
wiley   +1 more source

Predicting cardiovascular disease in peritoneal dialysis patients using glycated proteomics and machine learning: A prospective multicentre study

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Graphical Headlights 1. Glycated proteomics identified candidate cardiovascular biomarkers in peritoneal dialysis patients. 2. A machine learning model integrated two glycated peptides with six clinical indicators. 3. The model achieved ROC‐AUCs of 0.781 in the internal testing set and 0.822 in multicentre external validation.
Ji Ji, Zhaoying Nie, Na Jiang, Ting Xie, Lei Zhang, Xiaoyan Liu, Min Lu, Bo Xiang, Weiwei Wu, Xiaotian Jiang, Lin Zhang, Jun Ji, Jianzhou Zou, Xiaoqiang Ding, Haojie Lu, Xiaofang Yu   +15 more
wiley   +1 more source

Alpha 1 antitrypsin deficiency in non cystic fibrosis bronchiectasis

Egyptian Journal of Chest Disease and Tuberculosis, 2013
Setting: It is important to identify manifestations of alpha1-antitrypsin deficiency (A1ATD) in bronchiectasis to improve care and outcome in these patients.
Mohamed Shahat Badawy, Atef Farouk El Qarn, Hamdy Ali Mohamadeen   +2 more
doaj   +1 more source

Diagnosis of alpha-1 antitrypsin deficiency: a population-based study

, 2016
Miriam Barrecheguren,1,2 Mónica Monteagudo,3 Pere Simonet,3–5 Carl Llor,6 Esther Rodriguez,1,7 Jaume Ferrer,1,2,7 Cristina Esquinas,1 Marc Miravitlles1,2,7 1Department of Pneumology, Vall d´Hebron University Hospital, 2Medicine ...
Llor C, Ferrer J, Barrecheguren M, Esquinas C, Monteagudo M, Miravitlles M, Rodriguez E, Simonet P   +7 more
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