Results 111 to 120 of about 24,393 (190)

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Noninvasive Tests for Predicting Decompensation in Compensated Advanced Chronic Liver Disease: A Comprehensive Review

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Strong non‐invasive tests (NITs) are needed to predict decompensation in patients with compensated advanced chronic liver disease (cACLD) and improve personalized patient care. We conducted a comprehensive review of the studies evaluating the effectiveness of NITs in predicting decompensation or liver‐related death in patients with cACLD.
Audrey Payancé, Pierre‐Emmanuel Rautou, Jérôme Boursier, Laurent Castera, Dominique Valla, Laure Elkrief   +5 more
wiley   +1 more source

Hyaluronic Acid Decoration Facilitates CD44‐Mediated Targeting and Alters Protein Corona Formation of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Cell recognition and uptake of extracellular vesicles (EVs) is mediated by a variety of surface molecules. Growing interest has recently been drawn towards glycan structures on EVs. Hyaluronic acid (HA) is a negatively charged glycosaminoglycan that can decorate the surface of EVs from different origins.
Heikki Kyykallio, Elena Scurti, Martina Hanzlíková, Kirsti Härkönen, Tuovi Salo, Veera Keinonen, Janne Capra, Tapani Viitala, Jaakko Teppo, Tatu Lajunen, Kirsi Rilla   +10 more
wiley   +1 more source

Oxymatrine Inhibits Epithelial‐Mesenchymal Transition to Alleviate Airway Remodeling in Chronic Obstructive Pulmonary Disease by Suppressing the TGF‐β1/Smad Pathway

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 4, April 2026.
ABSTRACT This study explored the therapeutic efficacy of oxymatrine (OMT, C15H24N2O2) in a murine model of cigarette smoke (CS)‐induced chronic obstructive pulmonary disease (COPD) and elucidated its underlying mechanisms. A COPD model was established in mice through prolonged exposure to CS, followed by intraperitoneal administration of OMT (50 mg/kg)
Shuang Zhou, Ju‐Xiang Zhu, Jing Li
wiley   +1 more source

From Heterogeneity to Plasticity: Endothelial Dynamics in Lung Disease

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Endothelial heterogeneity and plasticity play an important role in lung development, homeostasis, and pathology. In recent years, increasing evidence has demonstrated that endothelial dysfunction contributes to the progression of various lung diseases, such as ADRS, PF, PH, and lung developmental disorders.
Van Dung Nguyen, Bisheng Zhou
wiley   +1 more source

Prevalence and risk factors for metabolic dysfunction–associated steatotic liver disease in Sweden: Insights from the SCAPIS cohort

Journal of Internal Medicine, Volume 299, Issue 4, Page 481-501, April 2026.
Abstract Background and Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disease globally, but its prevalence and severity remain poorly characterized in the general population. Our aim was to estimate the prevalence of MASLD and the risk of advanced fibrosis in a large Swedish general population ...
Oumarou Nabi, Jonas Spaak, Göran Bergström, Gunnar Engström, Carl Johan Östgren, Andrei Malinovschi, Joel Kullberg, Anders Blomberg, Tomas Jernberg, Daniel P. Andersson, Hannes Hagström   +10 more
wiley   +1 more source

MASLD Is Associated With Decreased General Health Perception, Quality of Life and Work Productivity in a Low Fibrosis Population

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background Data on quality of life in a low fibrosis prevalence metabolic dysfunction‐associated steatotic liver disease (MASLD) cohort are scarce, as previous research has focused on advanced fibrosis and cirrhosis. This study examined the association between steatosis and general and mental health, as well as productivity in patients in ...
L. J. M. Heyens, C. Van Steenkiste, M. Struyve, S. M. Francque, G. H. Koek, G. Robaeys, the MASLD Research Group, Y. Kockaerts, I. Lowyck, K. Stinkens, H. Van Leeuwen‐Wintjens, L. Vernijns, J. Germaux, T. Meyers, J. Gyselaers, S. Pietermans, R. Bollen, A. Robaeys, C. Gilio, R. Remmen, J. Muris, M. Uitterhoeve‐Prins, M. Bremers, L. van Bokhoven, K. de Munck, E. Rubens, K. Joris   +26 more
wiley   +1 more source

Long-term augmentation therapy with Alpha-1 Antitrypsin in an MZ-AAT severe persistent asthma [PDF]

, 2010
A young Caucasian female with severe bronchial asthma and Alpha1-antitrypsin (AAT) deficiency, MZ phenotype, experienced a quick and severe limitation of her physical capacity, which negatively affected her psychological state and social life, though she
Blanco, Ignacio, Bustillo, E.F. (E.), Camblor, C., Canto, H., Cárcaba, Victoriano, Flóres, J., Janciauskiene, Sabina, Serres, F.J. (Frederick)   +7 more
core  

Long-term augmentation therapy with Alpha-1 Antitrypsin in an MZ-AAT severe persistent asthma [PDF]

, 2009
Long-term augmentation therapy with Alpha- 1 Antitrypsin in an MZ-AAT severe persistent asthma. I. Blanco, H. Canto, J. Flóres, C. Camblor, V. Cárcaba, F.J. de Serres,S. Janciauskiene, E.F. Bustillo.
Blanco, Ignacio
core  

Tracing genetic diversity captures the molecular basis of misfolding disease

Nature Communications
Genetic variation in human populations can result in the misfolding and aggregation of proteins, giving rise to systemic and neurodegenerative diseases that require management by proteostasis.
Pei Zhao, Chao Wang, Shuhong Sun, Xi Wang, William E. Balch   +4 more
doaj   +1 more source