Results 151 to 160 of about 18,078,412 (185)

Reduced Alpha-2-Antiplasmin Levels in the Nephrotic Syndrome

Nephron, 2008
Venous and arterial thromboembolism frequently complicate the nephrotic syndrome. Increased platelet aggregation, high levels of fibrinogen and other procoagulants, and depressed levels of antithrombin III and plasminogen are commonly cited as reasons.
R B, Francis, R M, Sandler, D, Levitan, E I, Feinstein, S G, Massry, D I, Feinstein   +5 more
openaire   +2 more sources

The effects of alpha 2-antiplasmin complex and alpha 2-antiplasmin on the secretion of IgG and IgM by cultured human mononuclear cells.

Journal of clinical & laboratory immunology, 1998
We tested alpha 2-antiplasmin (AP) and its complex with plasmin (PL) for their capacity to modulate spontaneous secretion of immunoglobulins (Ig) G and M by mononuclear cells (MNC). MNC were obtained from peripheral blood of 10 donors (5 males and 5 females) and cultured for 7 days in the presence of various concentrations of AP and AP-PL complex.
S G, Zhabin, V S, Gorin
openaire   +2 more sources

Relationship between Elevated Fibrinopeptide A Levels and Alpha-2-Antiplasmin

Haemostasis, 2009
In order to investigate whether α₂-antiplasmin (α₂-AP) levels may be related to thrombin activity, we measured α₂-AP and fibrinopeptide A (FPA) in 51 patients with clinical conditions frequently associated with increased thrombin activity.
MARONGIU, FRANCESCO, Mulas G, Mamusa A. M, Mameli G, Marassi P. P, Tronci M. B, Cambuli A. B, Acca M. R, Balestrieri A. A.   +8 more
openaire   +3 more sources

[Alpha 2-antiplasmin in childhood].

Folia haematologica (Leipzig, Germany : 1928), 1982
In 119 children, predominantly newborns and babies with sepsis, alpha 2-Antiplasmin was determined by the use of the chromogenic substrate S-2251. In healthy newborns, the inhibitor level averaged 65 per cent of the adult level. Already in the initial phase of sepsis, enhanced alpha 2-antiplasmin values were observed.
G, Weissbach, M, Domula, K, Rieske
openaire   +1 more source

The alpha-2-antiplasmin Arg407Lys polymorphism is associated with Abdominal Aortic Aneurysm

Thrombosis Research, 2014
Abdominal Aortic Aneurysm (AAA) involves dilatation of the abdominal aorta, with a natural history of expansion and eventual rupture. We have previously shown that AAA patients form denser clots with smaller pores, which are more resistant to fibrinolysis.
Katherine I Bridge, Fraser L Macrae, Marc A Bailey   +2 more
exaly   +3 more sources

A familial hemorrhagic diathesis in a Dutch family: an inherited deficiency of alpha 2-antiplasmin [PDF]

Blood, 1982
Abstract This study concerns a case of congenital homozygous deficiency in alpha 2-antiplasmin associated with a severe hemorrhagic diathesis. Heterozygous family members also show a mild bleeding tendency. The propositus is a 17-yr-old male born of white parents and showing a severe hemorrhagic diathesis characterized by spontaneous ...
E Vellenga, G Wijngaards, Vellenga E
exaly   +5 more sources

Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites

Science, 1988
Although the proteinase inhibitor alpha-2-antiplasmin (α 2 AP) is known to control the activity of plasmin through rapid formation of stable complexes, it also efficiently inactivates chymotrypsin. These interactions are shown to occur at adjacent, overlapping sites so that plasmin attacks the inhibitor at an Arg
Jan Potempa
exaly   +3 more sources

Amino-acid sequence of human alpha 2-antiplasmin.

European journal of biochemistry, 1987
The amino-acid sequence of human alpha 2-antiplasmin was determined by Edman degradation of peptides purified from CNBr, tryptic and chymotryptic digests. Of the total sequence of 452 amino acids of mature alpha 2-antiplasmin, as deduced from the cDNA sequence [Holmes et al. (1987) J. Biol. Chem.
H R, Lijnen, W E, Holmes, B, van Hoef, B, Wiman, H, Rodriguez, D, Collen   +5 more
openaire   +2 more sources

[Alpha 2-antiplasmin in bovine plasma].

Ukrainskii biokhimicheskii zhurnal (1978), 1985
Bovine and human blood plasma contains alpha 2-antiplasmin which possesses affinity to lysin-binding sites in plasmin and inhibits the human plasmin. Its isolation was conducted for two stages: separation of plasminogen on lysin-cellulose, fractionation by ammonium sulphate, desalination on molselector G-25, chromatography on DEAE-Sephadex A-50 and ...
A S, Piliavskaia, N E, Panchenko
openaire   +1 more source

Appropriate Milieu for the Assay of Alpha-2-Antiplasmin Activity with Chromogenic Substrates

Haemostasis, 2009
Inhibition reference curves for α₂-antiplasmin showed a deviation from linearity at low inhibitor concentrations using the chromogenic substrate S-2251. Extrapolation of these curves to zero inhibition gave higher amidolytic activities than actually recorded with the free enzyme plasmin.
C, Kluft, G, Wijngaards, A F, Jie, E, Groeneveld   +3 more
openaire   +2 more sources