Results 151 to 160 of about 105,578,950 (193)

Alpha 2-Antiplasmin Enschede: Dysfunctional Alpha 2-Antiplasmin Molecule Associated With an Autosomal Recessive Hemorrhagic Disorder. [PDF]

Journal of Clinical Investigation, 1987
alpha 2-Antiplasmin (alpha 2-AP) is a major fibrinolysis inhibitor, whose complete, congenital absence has been found to be associated with a distinct hemorrhagic diathesis. We studied a 15-yr-old male with a hemorrhagic diathesis after trauma from early childhood on.
Willem J.H. van Berkel, E Groeneveld, G Wijngaards   +2 more
exaly   +3 more sources

The Presence and Release of Alpha 2-Antiplasmin From Human Platelets [PDF]

Blood, 1981
An antigen immunochemically indistinguishable from plasma alpha 2- antiplasmin, the primary plasmin inhibitor, was detected in human platelets. By radioimmunoassay, 33–114 ng alpha 2-antiplasmin antigen was quantitated in the detergent-soluble extract of 10(9) washed human platelets from 10 normal donors with a mean level of 62 +/- 24 ng/10(9 ...
Ef Plow, D Collen
exaly   +4 more sources

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Alpha-2-Antiplasmin in Acute Nonlymphoblastic Leukemia

Acta Haematologica, 2009
The levels of alpha-2-antiplasmin (α₂-AP), antithrombin III (At III) and plasminogen were studied in 21 patients with acute nonlymphoblastic leukemia (ANLL) before and after induction chemotherapy and during bone marrow cellularity recovery after the postchemotherapy aplastic phase.
E, Cofrancesco, E, Pogliani, M, Salvatore, G, Moreo, C, Boschetti, M, Cortellaro   +5 more
openaire   +2 more sources

Reduced Alpha-2-Antiplasmin Levels in the Nephrotic Syndrome

Nephron, 2008
Venous and arterial thromboembolism frequently complicate the nephrotic syndrome. Increased platelet aggregation, high levels of fibrinogen and other procoagulants, and depressed levels of antithrombin III and plasminogen are commonly cited as reasons.
R B, Francis, R M, Sandler, D, Levitan, E I, Feinstein, S G, Massry, D I, Feinstein   +5 more
openaire   +2 more sources

Plasma Levels of Soluble Fibroblast Activation Protein in Arterial Thrombosis; Determinants and Cleavage of Its Substrate Alpha-2-Antiplasmin

International Journal of Cardiology, 2015
Background: Fibroblast activation protein (FAP) is a transmembrane glycoprotein with dipeptidyl-peptidase and endopeptidase activities and circulates in blood in a truncated, soluble form (sFAP). Fibrinolysis inhibitor alpha 2-antiplasmin (alpha 2AP) has
Frank Leebeek, Shirley Uitte de Willige, Jaap W Deckers   +2 more
exaly   +2 more sources

Alpha-2-Antiplasmin: A Serpin With Two Separate but Overlapping Reactive Sites

Science, 1988
Although the proteinase inhibitor alpha-2-antiplasmin (α 2 AP) is known to control the activity of plasmin through rapid formation of stable complexes, it also efficiently inactivates chymotrypsin. These interactions are shown to occur at adjacent, overlapping sites so that plasmin attacks the inhibitor at an Arg
J Travis
exaly   +3 more sources

Acquired alpha‐2‐antiplasmin deficiency in acute promyelocytic leukaemia

British Journal of Haematology, 1988
We report a prospective study in nine consecutive adult patients with acute promyelocytic leukaemia (APL). The study objective was to assess the prevalance of activation of blood coagulation and/or activation of fibrinolysis in APL. Coagulation and fibrinolytic parameters relevant to the objective included antithrombin III, plasminogen, fibrin ...
Avvisati, G., ten Cate, J. W., Sturk, A., Lamping, R., Petti, M. G., Mandelli, F.   +5 more
openaire   +2 more sources

The effects of alpha 2-antiplasmin complex and alpha 2-antiplasmin on the secretion of IgG and IgM by cultured human mononuclear cells.

Journal of clinical & laboratory immunology, 1998
We tested alpha 2-antiplasmin (AP) and its complex with plasmin (PL) for their capacity to modulate spontaneous secretion of immunoglobulins (Ig) G and M by mononuclear cells (MNC). MNC were obtained from peripheral blood of 10 donors (5 males and 5 females) and cultured for 7 days in the presence of various concentrations of AP and AP-PL complex.
S G, Zhabin, V S, Gorin
openaire   +2 more sources

Relationship between Elevated Fibrinopeptide A Levels and Alpha-2-Antiplasmin

Haemostasis, 2009
In order to investigate whether α₂-antiplasmin (α₂-AP) levels may be related to thrombin activity, we measured α₂-AP and fibrinopeptide A (FPA) in 51 patients with clinical conditions frequently associated with increased thrombin activity.
MARONGIU, FRANCESCO, Mulas G, Mamusa A. M, Mameli G, Marassi P. P, Tronci M. B, Cambuli A. B, Acca M. R, Balestrieri A. A.   +8 more
openaire   +3 more sources

[Alpha 2-antiplasmin in childhood].

Folia haematologica (Leipzig, Germany : 1928), 1982
In 119 children, predominantly newborns and babies with sepsis, alpha 2-Antiplasmin was determined by the use of the chromogenic substrate S-2251. In healthy newborns, the inhibitor level averaged 65 per cent of the adult level. Already in the initial phase of sepsis, enhanced alpha 2-antiplasmin values were observed.
G, Weissbach, M, Domula, K, Rieske
openaire   +1 more source