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Supplemental Alpha-2-Antiplasmin Prevents Plasmin-Induced Hemorrhage.
Blood, 2004Abstract Plasmin is a direct-acting thrombolytic agent with an impressive safety margin in experimental models, as it is tolerated without bleeding at a 6-fold greater dose than needed for thrombolysis. At higher plasmin dosages, above a reproducible dose threshold, alpha-2-antiplasmin (AP) is consumed, accompanied by complete depletion ...
Daphne Stewart +7 more
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Alpha 2-antiplasmin deficiency. An overlooked cause of hemorrhage.
The American journal of pediatric hematology/oncology, 1993Alpha 2-Antiplasmin (AP) deficiency is a rare congenital bleeding disorder that presents with normal screening tests for platelet function and clotting. We believe that this disorder is frequently overlooked, especially in women with unexplained bleeding.We report on two families and one single patient with heterozygous AP deficiency.All patients and ...
G C, Griffin +5 more
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[Methods of studying alpha 2-antiplasmin activity].
Voprosy meditsinskoi khimii, 1992Methods of alpha 2-antiplasmin (AP) study are reviewed. Estimation of the AP concentration, content of the plasmin-AP complex and of functional AP activity are discussed.
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Alpha 2-antiplasmin Enschede is not an inhibitor, but a substrate, of plasmin.
The Biochemical journal, 1989alpha 2-Antiplasmin Enschede is a variant of alpha 2-antiplasmin which has lost its ability to inhibit plasmin irreversibly and which is associated with a haemorrhagic disorder [Kluft et al. (1987) J. Clin. Invest. 80, 1391-1400]. The abnormal protein was purified from the plasma of a homozygous patient and subjected to one-dimensional peptide mapping ...
D C, Rijken +3 more
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Promotion of the crosslinking of fibrin and alpha 2-antiplasmin by platelets.
Thrombosis and haemostasis, 1997Factor XIII (FXIII) is of high importance in the regulation of fibrinolysis. It crosslinks alpha 2-antiplasmin (alpha 2AP) and fibrin and by this way protects fibrin from the prompt elimination by plasmin. Although FXIII of platelets has been implicated in this protective mechanism, the role of platelets and platelet FXIII in the crosslinking process ...
Z, Hevessy +4 more
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Congenital deficiencies in α2-antiplasmin
La Ricerca in Clinica e in Laboratorio, 1984KLUFT, C, NIEUWENHUIS, HK, VELLENGA, E
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