Results 161 to 170 of about 105,578,950 (193)

Amino-acid sequence of human alpha 2-antiplasmin.

European journal of biochemistry, 1987
The amino-acid sequence of human alpha 2-antiplasmin was determined by Edman degradation of peptides purified from CNBr, tryptic and chymotryptic digests. Of the total sequence of 452 amino acids of mature alpha 2-antiplasmin, as deduced from the cDNA sequence [Holmes et al. (1987) J. Biol. Chem.
H R, Lijnen, W E, Holmes, B, van Hoef, B, Wiman, H, Rodriguez, D, Collen   +5 more
openaire   +2 more sources

The Alpha-2-Antiplasmin Arg407Lys Polymorphism Is Associated With Abdominal Aortic Aneurysm

Thrombosis Research, 2014
Abdominal Aortic Aneurysm (AAA) involves dilatation of the abdominal aorta, with a natural history of expansion and eventual rupture. We have previously shown that AAA patients form denser clots with smaller pores, which are more resistant to fibrinolysis.
Marc Bailey, Robert A S Ariëns, Fraser L Macrae   +2 more
exaly   +3 more sources

[Alpha 2-antiplasmin in bovine plasma].

Ukrainskii biokhimicheskii zhurnal (1978), 1985
Bovine and human blood plasma contains alpha 2-antiplasmin which possesses affinity to lysin-binding sites in plasmin and inhibits the human plasmin. Its isolation was conducted for two stages: separation of plasminogen on lysin-cellulose, fractionation by ammonium sulphate, desalination on molselector G-25, chromatography on DEAE-Sephadex A-50 and ...
A S, Piliavskaia, N E, Panchenko
openaire   +1 more source

Appropriate Milieu for the Assay of Alpha-2-Antiplasmin Activity with Chromogenic Substrates

Haemostasis, 2009
Inhibition reference curves for α₂-antiplasmin showed a deviation from linearity at low inhibitor concentrations using the chromogenic substrate S-2251. Extrapolation of these curves to zero inhibition gave higher amidolytic activities than actually recorded with the free enzyme plasmin.
C, Kluft, G, Wijngaards, A F, Jie, E, Groeneveld   +3 more
openaire   +2 more sources

Supplemental Alpha-2-Antiplasmin Prevents Plasmin-Induced Hemorrhage.

Blood, 2004
Abstract Plasmin is a direct-acting thrombolytic agent with an impressive safety margin in experimental models, as it is tolerated without bleeding at a 6-fold greater dose than needed for thrombolysis. At higher plasmin dosages, above a reproducible dose threshold, alpha-2-antiplasmin (AP) is consumed, accompanied by complete depletion ...
Daphne Stewart, Victor J. Marder, Mansze Kong, Doris Quon, Scott A. Cook, Gary Jesmok, Peter Radtke, George A. Baumbach   +7 more
openaire   +1 more source

Alpha 2-antiplasmin deficiency. An overlooked cause of hemorrhage.

The American journal of pediatric hematology/oncology, 1993
Alpha 2-Antiplasmin (AP) deficiency is a rare congenital bleeding disorder that presents with normal screening tests for platelet function and clotting. We believe that this disorder is frequently overlooked, especially in women with unexplained bleeding.We report on two families and one single patient with heterozygous AP deficiency.All patients and ...
G C, Griffin, E F, Mammen, R J, Sokol, A L, Perrotta, A, Stoyanovich, C F, Abildgaard   +5 more
openaire   +1 more source

Alpha 2-antiplasmin Enschede is not an inhibitor, but a substrate, of plasmin.

The Biochemical journal, 1989
alpha 2-Antiplasmin Enschede is a variant of alpha 2-antiplasmin which has lost its ability to inhibit plasmin irreversibly and which is associated with a haemorrhagic disorder [Kluft et al. (1987) J. Clin. Invest. 80, 1391-1400]. The abnormal protein was purified from the plasma of a homozygous patient and subjected to one-dimensional peptide mapping ...
D C, Rijken, E, Groeneveld, C, Kluft, H K, Nieuwenhuis   +3 more
openaire   +1 more source

HOMOZYGOUS $alpha;2-ANTIPLASMIN DEFICIENCY

The Lancet, 1979
KLUFT, C, VELLENGA, E, BROMMER, EJP
openaire   +3 more sources

[Methods of studying alpha 2-antiplasmin activity].

Voprosy meditsinskoi khimii, 1992
Methods of alpha 2-antiplasmin (AP) study are reviewed. Estimation of the AP concentration, content of the plasmin-AP complex and of functional AP activity are discussed.
openaire   +1 more source

Promotion of the crosslinking of fibrin and alpha 2-antiplasmin by platelets.

Thrombosis and haemostasis, 1997
Factor XIII (FXIII) is of high importance in the regulation of fibrinolysis. It crosslinks alpha 2-antiplasmin (alpha 2AP) and fibrin and by this way protects fibrin from the prompt elimination by plasmin. Although FXIII of platelets has been implicated in this protective mechanism, the role of platelets and platelet FXIII in the crosslinking process ...
Z, Hevessy, G, Haramura, Z, Boda, M, Udvardy, L, Muszbek   +4 more
openaire   +1 more source