Results 11 to 20 of about 2,093 (106)

Promotion of the resistance of human oral epithelial cells to herpes simplex virus type I infection via N6-methyladenosine modification

BMC Oral Health, 2023
Objective This study aimed to explore the mechanism behind N6-methyladenosine (m6A) modification of the total ribonucleic acid (RNA) involved in the resistance to herpes simplex virus type I (HSV-1) infection in oral epithelial cells.
Junping Xu, Yuping Qi, Qi Ju
doaj   +1 more source

Investigation of the association of AGTR1 A1166C rs5186 and FTO rs9939609 polymorphisms with the obesity in children and adolescents

مجلة بغداد للعلوم, 2022
Obesity is a risk factor for a number of chronic conditions. Obesity is clinically defined using the body mass index (BMI) as weight in kg divided by (height)2 in m2 correlated with obesity. Currently, genetic markers of obesity are being studied.
Alaa Hashim Abd Ali, Teplyakova E. D., Bocharova O. V., Karantysh G. V., Shkurat T. P.   +4 more
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m 6A RNA Methylation Decreases Atherosclerotic Vulnerable Plaque Through Inducing T Cells

Brazilian Journal of Cardiovascular Surgery, 2022
Introduction: Knockdown of fat mass and obesity-associated gene (FTO) can induce N6-methyladenosine (m 6A) ribonucleic acid (RNA) methylation. The objective of this study was to explore the effect of m 6A RNA methylation on atherosclerotic vulnerable ...
Chunmei Qi, Haoran Li, Yongshu Yu, Ji Hao, Hao Zhang, Lele Wang, Jingjing Jin, Qiang Zhou, Ya Hu, Chengmeng Zhang, Qingdui Zhang   +10 more
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Psoriasis and metabolic syndrome: a review

Ожирение и метаболизм, 2020
Psoriasis is the most common chronic dermatosis and affects 1–2% of the population of developed countries. In Russia, psoriasis incidence rate has increased by 11% since 2011. Psoriasis is a chronic inflammatory and immune-mediated skin disease and it is
M. A. Ufimtseva, A. A. Popov, L. V. Fedotova, E. S. Mylnikova, Yu. M. Bochkarev, D. S. Zhunisova   +5 more
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m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2

Cell Death Discovery, 2021
Both N6-methyladenosine (m6A) RNA modification and microRNAs (miRNAs) are common regulatory mechanisms for gene post-transcription by modulating mRNA stability and translation.
Benheng Qian, Ping Wang, Donghong Zhang, Lianpin Wu   +3 more
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Effect of M6A regulators on diagnosis, subtype classification, prognosis and novel therapeutic target development of idiopathic pulmonary fibrosis

Frontiers in Pharmacology, 2022
Molecular biology studies show that RNA N6-methyladenosine (m6A) modifications may take part in the incidence and development of idiopathic pulmonary fibrosis (IPF). Nonetheless, the roles of m6A regulators in IPF are not fully demonstrated.
Guirui Huang, Shuaiyang Huang, Hongsheng Cui   +2 more
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Nutritional interventions in treatment of psoriasis and metabolic syndrome

Лечащий Врач, 2021
Psoriasis is a common chronic dermatosis associated with metabolic syndrome and its components. Metabolic syndrome contributes to severe psoriasis. Obesity is a multifactorial disease and its development is influenced by genetic factors.
M. A. Ufimtseva, A. A. Popov, L. V. Fedotova, E. S. Mylnikova, Yu. M. Bochkarev, D. S. Zhunisova   +5 more
doaj   +1 more source

A multi-omics analysis identifies molecular features associated with fertility in heifers (Bos taurus)

Scientific Reports, 2023
Infertility or subfertility is a critical barrier to sustainable cattle production, including in heifers. The development of heifers that do not produce a calf within an optimum window of time is a critical factor for the profitability and sustainability
Mackenzie A. Marrella, Fernando H. Biase
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FTO attenuates TNF-α-induced damage of proximal tubular epithelial cells in acute pancreatitis-induced acute kidney injury via targeting AQP3 in an N6-methyladenosine-dependent manner

Renal Failure
Background Acute kidney injury (AKI) is a frequent complication of severe acute pancreatitis (SAP). Previous investigations have revealed the involvement of FTO alpha-ketoglutarate-dependent dioxygenase (FTO) and aquaporin 3 (AQP3) in AKI. Therefore, the
Xinghui Li, Qi Liang, Lu Liu, Shujun Chen, Yong Li, Yu Pu   +5 more
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The pseudorabies virus UL13 protein kinase triggers phosphorylation of the RNA demethylase FTO, which is associated with FTO-dependent suppression of interferon-stimulated gene expression

Journal of Virology
Alpha-ketoglutarate-dependent dioxygenase, also known as fat mass and obesity-associated protein (FTO), is an RNA demethylase that mediates the demethylation of N6,2-O-dimethyladenosine (m6Am) and N6-methyladenosine (m6A). Both m6Am and m6A are prevalent
Ruth Verhamme, Robert J. J. Jansens, Jianheng Liu, Fien Van Raemdonck, Cliff Van Waesberghe, Luke Nicholson, Samie R. Jaffrey, Herman W. Favoreel   +7 more
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