Results 31 to 40 of about 2,093 (106)

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, Volume 13, Issue 17, 23 March 2026.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Glycolysis enzymes and cellular lactylation in tumour

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Graphical Headlights • Glycolytic enzymes regulate lactylation in cancer cells. • Lactylation drives tumour growth, metastasis, immune evasion and contributes to microenvironment remodelling. • Targeting lactylation holds promise for cancer therapy. Abstract Cellular lactylation, a recently identified post‐translational modification, has emerged as a ...
Chenyuan Dai, Lihua Wang
wiley   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Coevolution of the Human Brain and Microbiome: Roles of Accelerated Regions and Maternal Microbiota in Neurodevelopment

Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
The coevolution of the human brain and microbiome has emerged as a pivotal area of research, highlighting the interactions that have shaped human development. Human accelerated regions (HARs), which are genomic sequences that evolved rapidly in humans, play an important role in brain development, influencing cognitive functions and susceptibility to ...
Siddharth Singh, Vaishali Saini, Meenakshi Kandpal, Trushnal S. Waghmare, Bhupesh K. Prusty, Hem Chandra Jha, Jiong Yu   +6 more
wiley   +1 more source

FTO and NOS3 genes associated with pediatric obesity: Corações de Ouro Preto study

BMC Pediatrics
Background Obesity is the largest global public health epidemic, increasingly affecting children and adolescents. Studies suggest that genetic markers such as single nucleotide polymorphisms (SNPs) may be associated with the development of obesity ...
Aline Priscila Batista, Thomás Viana de Souza, Luiz Antônio Alves de Menezes-Júnior, Anna Carolina Motta Costa, Camila Blanco Cangussu, Luciano Garcia Lourenção, Wandeir Wagner de Oliveira, Gabriel Trindade Avelar, Daniela Fonseca Abdo Rocha, Iriane Marques de Carvalho Rodrigues, André Versiani Caldeira Rocha, Joana Paula Mendes de Moura, George Luiz Lins Machado-Coelho   +12 more
doaj   +1 more source

Genome‐Wide Cross‐Trait Analysis Dissects the Shared Genetic Architecture Between Type 2 Diabetes Mellitus and Metabolic Dysfunction–Associated Steatotic Liver Disease

Human Mutation, Volume 2026, Issue 1, 2026.
The observational studies confirmed the high prevalence of metabolic dysfunction–associated steatotic liver disease (MASLD) in patients with Type 2 diabetes mellitus (T2DM), but whether this reflects a shared genetic etiology and exists underlying causal relationships remains unknown. Here, we utilized the largest scale cross‐trait analysis from genome‐
Zijun Zhu, Hailong Li, Xin Wang, Xinyu Chen, Liang Cheng, Priya Gusain   +5 more
wiley   +1 more source

Genome‐wide identification of MsAlkB family genes and functional analysis of MsALKBH2 as an RNA m6A eraser in alfalfa (Medicago sativa L.) subject to drought stress

Grassland Research, Volume 4, Issue 4, Page 316-331, December 2025.
MsALKBH2 is an mRNA m6A demethylase in alfalfa that is required for enhancing drought tolerance through decreasing ROS content. Abstract Background N6‐methyladenosine (m6A), the most prevalent mRNA modification in plants, plays a pivotal role in developmental processes and stress responses.
Xianglong Zhao, Jie Zhao, Hui Zhang, Yan Li, Chao Sui, Wengang Xie, Zhipeng Liu, Mingjia Chen, Wenxian Liu   +8 more
wiley   +1 more source

Six Years of Genetic Diagnosis of Severe Early‐Onset Obesity in a French Cohort

Obesity Science &Practice, Volume 11, Issue 6, December 2025.
ABSTRACT Objective Obesity is a multifactorial disease with a strong genetic component. It is imperative to enhance the identification of genetic variations in their early and severe manifestations in order to facilitate the development of personalized therapeutic strategies, informed clinical care, and the facilitation of genetic counseling.
M. Rama, E. Blond, A. Janin, M. Di‐Filippo, C. Cuerq, O. Marmontel, P. A. Rollat‐Farnier, E. Dieterlen, B. Segrestin, M. Nicolino, E. Disse, K. Perge, D. Collin‐Chavagnac   +12 more
wiley   +1 more source

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, Volume 26, Issue 12, December 2025.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source

白N6-甲基腺苷修饰及其调控蛋在脑缺血中的表达变化及意义 Expression Changes and Significance of N6-Methyladenosine and its Regulatory Proteins in Cerebral Ischemia

Zhongguo cuzhong zazhi
目的 本研究通过探讨N6-甲基腺苷（N6-methyladenosine，m6A）修饰及其调控蛋白在脑缺血小鼠中的表达变化，为脑缺血治疗的分子靶点研究提供参考。 方法 取60只雄性C57BL/6J小鼠，随机分为假手术组、脑缺血1 d组、脑缺血3 d组和脑缺血7 d组，每组各15只，采用线栓法制作右侧大脑中动脉梗死模型，于缺血1 h进行拔栓再灌注。通过RNA提取及斑点印迹实验检测小鼠缺血侧脑组织RNA m6A水平；使用荧光定量逆转录PCR检测小鼠缺血侧脑组织甲基转移酶3 ...
叶维贞，赵顺英，姜鸣钰，黄秋茹，温少红，董雯，陈青芳，刘向荣(YE Weizhen, ZHAO Shunying, JIANG Mingyu, HUANG Qiuru, WEN Shaohong, DONG Wen, CHEN Qingfang, LIU Xiangrong)
doaj   +1 more source