Results 101 to 110 of about 10,436 (217)

Optimization of metal-cyclization of alpha-MSH peptide analogs used in the treatment and detection of melanoma [PDF]

, 2005
only availableOver the past few years Dr. Quinn and his lab have made significant progress in the development of a melanoma treatment drug. Based upon peptide analogs of the alpha-melanocyte stimulating hormone, Α-MSH, Dr.
Butcher, Clayton, Gallazzi, Fabio, Quinn, Thomas P. (Thomas Patrick), 1961-   +2 more
core  

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. [PDF]

, 2018
Most monogenic cases of obesity in humans have been linked to mutations in genes encoding members of the leptin-melanocortin pathway. Specifically, mutations in MC4R, the melanocortin-4 receptor gene, account for 3-5% of all severe obesity cases in ...
A Hinney, A Marley, A Shalata, Aaron Marley, Adelaide A. Bernard, AS Garfield, BA Ersoy, Baran A. Ersoy, C Lubrano-Berthelier, C Lubrano-Berthelier, C Vaisse, C Vaisse, C Vaisse, Christian Vaisse, D Huszar, E Stergiakouli, F Hildebrandt, GA Bishop, GJ Morton, H Fenselau, JA Green, Jacqueline E. Siljee, Jeremy F. Reiter, JF Reiter, JR Davenport, KC Corbit, L Wu, M Calton, Mark Von Zastrow, MJ Krashes, N Balthasar, NF Berbari, P Aanstad, P Acs, SC Goetz, Sumei Zhang, Y Bromberg, Yi Wang, Z Wang   +38 more
core   +1 more source

Thixotropic and Mechanical Behavior of MgO–SiO2 Pastes Incorporating Rice Husk Ash for Extrusion‐Based 3D Printing

Journal of the American Ceramic Society, Volume 109, Issue 2, February 2026.
ABSTRACT Rice husk ash (RHA) is an agricultural by‐product that can replace microsilica (MS) as a suitable silica source in MgO–SiO2 cement mixes, offering low‐carbon benefits. This study investigated the 3D printing properties, including thixotropy and hardened mechanical properties, of the MgO–SiO2 system formed by partial and total replacement of MS
Yiming Peng, Cise Unluer
wiley   +1 more source

Probing the Role of Melanocortin Type 1 Receptor Agonists in Diverse Immunological Diseases

Frontiers in Pharmacology, 2019
Background: The melanocortin α-melanocyte stimulating hormone (α-MSH), an endogenous peptide with high affinity for the melanocortin 1 receptor (MC1r), has demonstrated prevention and reversal of intestinal and ocular inflammation in animal models ...
Carl Spana, Andrew W. Taylor, David G. Yee, Marie Makhlina, Wei Yang, John Dodd   +5 more
doaj   +1 more source

COSMOS 2044. Experiment K-7-19. Pineal physiology in microgravity: Relation to rat gonadal function [PDF]

It is now known that the pineal organ can interact with many endocrine and nonendocrine tissues in a regulatory fashion. Given its key role in the regulation of melatonin synthesis, its high concentration, and that its levels may persist longer than the ...
Asadi, H., Holley, D., Krasnov, I., Soliman, M. R. I.   +3 more
core   +1 more source

In Vitro, Ex Vivo and Clinical Trial of Brightening Serum Using a Novel Delivery System on Subjects With Moderate to Severe Dyschromia

Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background/Aims Pigmentary problems are common and can arise from sun exposure, skin inflammation, changes in hormones, and certain medications. Because they are visible, these pigmentary problems can be very distressing for individuals, and they are often challenging to manage.
Ashish C. Bhatia, Arisa Ortiz, Swati Kannan, Amir Moradi, Tina Fleck, Robert Love, Stacy Osborne   +6 more
wiley   +1 more source

A mixture of seaweed extracts and glycosaminoglycans from sea squirts inhibits α-MSH-induced melanogenesis in B16F10 melanoma cells

Fisheries and Aquatic Sciences, 2019
Background In the present study, the skin-whitening effects of a marine-sourced mixture that includes a fucoidan-rich extract of Undaria pinnatifida (UPEF), a phlorotannin-rich extract of Ecklonia cava (ECE), and glycosaminoglycans (GAGs) from sea squirt
Lei Wang, Yong Ri Cui, Hye-Won Yang, Hyo Geun Lee, Ju-Young Ko, You-Jin Jeon   +5 more
doaj   +1 more source

Agouti related protein (AgRP) is upregulated in Cushing's syndrome. [PDF]

, 2005
Alpha melanocyte-stimulating hormone (alpha-MSH) is an agonist at the melanocortin 3 (MC3-R) and melanocortin 4 (MC4-R) receptors. alpha-MSH stimulates corticosterone release from rat and human adrenal cells.
Bewick, GA, Bloom, SR, Castle, L, Dhillo, WS, Gardiner, JV, Ghatei, MA, Meeran, K, Smith, KL, Todd, JF   +8 more
core   +1 more source

Effects of alpha-MSH on corneal epithelial lesions in rats.

Collegium antropologicum, 2012
We investigated the influence of alpha-melanocyte stimulating hormone (alpha-MSH) on the healing of corneal epithelial lesions in male Wistar rats. The lesions were induced by abrading corneal epithelium with a surgical lancet under a biomicroscope. Before the abrasion corneal epithelium was softened with 40% ethanol. alpha-MSH drops in a concentration
Pavan, Josip, Lukenda, Adrian, Stambuk, Nikola, Konjevoda, Pasko, Kastelan, Snjezana, Curkovic, Marko   +5 more
openaire   +4 more sources

Statistical Estimate of the Magnetopause Reconnection Rate as a Function of the Interplanetary Magnetic Field Clock Angle

Geophysical Research Letters, Volume 53, Issue 1, 16 January 2026.
Abstract The magnetic reconnection rate at the magnetopause is crucial for solar wind and magnetosphere coupling. However, direct measurement is challenging due to inherent uncertainties and limited electron diffusion region statistics, hindering understanding of the guide field's influence on the normalized reconnection rate.
B. Michotte de Welle, N. Aunai, B. Lavraud, V. Génot, G. Nguyen, A. Ghisalberti, A. Jeandet, D. Sibeck, H. Connor   +8 more
wiley   +1 more source