Results 141 to 150 of about 8,015 (172)

[Alpha-MSH and pregnancy].

Zeitschrift fur Hautkrankheiten, 1989
In 32 pregnant women, we repeatedly determined the levels of alpha-MSH, melatonin, ACTH and progesterone. In the radioimmunoassay, all of these hormones showed a significant increase from the first to the third trimester. In contrast to progesterone, neither the level of alpha-MSH nor that of melatonin rises significantly until between the 28th and ...
P, Altmeyer, A, Bernd, H, Holzmann, M, Bacharach-Buhles, E, Halberstadt   +4 more
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The neuroimmunomodulatory peptide alpha-MSH.

Annals of the New York Academy of Sciences, 2001
Alpha-melanocyte-stimulating hormone (alpha-MSH), a neuroimmunomodulatory peptide of ancient origin, is known to be involved in the control of host responses. In inflammatory cells, in the periphery and within the central nervous system, alpha-MSH modulates the production and action of proinflammatory cytokines.
T, Ichiyama, S, Sato, K, Okada, A, Catania, J M, Lipton   +4 more
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The neuropeptide alpha-MSH in host defense.

Annals of the New York Academy of Sciences, 2000
The presence of the ancient peptide alpha-melanocyte-stimulating hormone (alpha-MSH) in barrier organs such as gut and skin suggests that this potent anti-inflammatory molecule may be a component of the innate host defense. In tests of antimicrobial activities, alpha-MSH and its fragment KPV showed inhibitory influences against the gram-positive ...
A. Catania, M. Cutuli, L. Garofalo, A. Carlin, L. Airaghi, W. Barcellini, J. M. Lipton   +6 more
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Central alpha-MSH, energy balance, thermal balance, and antipyresis

Journal of Thermal Biology, 2010
Abstract Intracerebroventricular administration of alpha-MSH in young adult rats enhanced metabolic rate and caused a dose-dependent suppression of food intake, exhibiting a coordinated catabolic pattern. However, the thermoregulatory effects did not seem to be coordinated: the rising heat production was accompanied by a practically simultaneous ...
M. Balaskó, A. Garami, S. Soós, M. Koncsecskó-Gáspár, M. Székely, E. Pétervári   +5 more
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Age-related alterations in the central thermoregulatory responsiveness to alpha-MSH

Journal of Thermal Biology, 2015
Alpha-melanocyte-stimulating-hormone (alpha-MSH) is a neuropeptide that induces weight loss via its anorexigenic and hypermetabolic/hyperthermic effects. Two major public health problems of the human population involving energy balance (i.e. middle-aged obesity and aging cachexia) also appear in other mammals, therefore age-related regulatory ...
I, Rostás, N, Füredi, J, Tenk, A, Mikó, M, Solymár, S, Soós, M, Székely, E, Pétervári, M, Balaskó   +8 more
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Central administration of alpha-MSH antiserum augments fever in the rabbit

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1986
alpha-Melanocyte-stimulating hormone (alpha-MSH) has a marked antipyretic action when given centrally or peripherally, and the concentration of this peptide within the septal region of the brain increases during fever. To assess the significance of endogenous central alpha-MSH in fever, antiserum was given to rabbits via a cannula implanted in the ...
S T, Shih, O, Khorram, J M, Lipton, S M, McCann   +3 more
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CSF alpha-MSH in dementia of the Alzheimer type.

Neurology, 1988
We measured CSF alpha-melanocyte stimulating hormone-like immunoreactivity (alpha-MSH-LI) in 35 patients with dementia of the Alzheimer type (DAT) and in 27 healthy control subjects. Mean alpha-MSH-LI concentration was significantly decreased in DAT patients as compared with age-matched controls.
RAINERO, Innocenzo, MAY C, KAYE JA, FRIEDLAND RP, RAPOPORT SI   +4 more
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alpha-MSH-induzierte anorexigene Signalwege in murinen Hypothalamuszellen

2013
In der deutschen Bevölkerung leidet, bezogen auf den BMI (Body-Mass-Index), etwa jeder zweite an Übergewicht. Innerhalb dieser Gruppe müssen dabei über 25 % als krankhaft adipös eingestuft werden. Trotz der weiten Verbreitung, ist zurzeit weder eine erfolgreiche medikamentöse Therapie der Adipositas verfügbar, noch sind die grundlegenden Mechanismen ...
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Synthesis of cyclic alpha-MSH peptides

1998
Cyclic lactam analogs of α-melanocyte stimulating hormone (α-MSH) have been shown to be potent agonists in the frog skin bioassay [Al-Obeidi, F. et al., J. Med. Chem., 32 (1989) 2555], demonstrating melanocortin-1 (MC1) receptor activity. We synthesized cyclic α-MSH(1-13) and α-MSH(4-10) lactam analogs.
Schaaper, W.M.M., Adan, R.A.H., Posthuma, T.A., Oosterom, J., Gispen, W.H., Meloen, R.H.   +5 more
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Is alpha-MSH deficiency the cause of Alzheimer's disease?

Medical Hypotheses, 1986
The hypothesis is that a functional deficiency of alpha-melanotropin (alpha-MSH) is the primary event in the development of Alzheimer's disease. Beginning with the concept that Alzheimer's disease occurs because of a deficiency of a neurotrophic factor specific for central cholinergic neurons data is then presented to support the hypothesis that alpha ...
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