Results 151 to 160 of about 8,293 (202)

The neuropeptide alpha-MSH in host defense.

Annals of the New York Academy of Sciences, 2000
The presence of the ancient peptide alpha-melanocyte-stimulating hormone (alpha-MSH) in barrier organs such as gut and skin suggests that this potent anti-inflammatory molecule may be a component of the innate host defense. In tests of antimicrobial activities, alpha-MSH and its fragment KPV showed inhibitory influences against the gram-positive ...
A. Catania, M. Cutuli, L. Garofalo, A. Carlin, L. Airaghi, W. Barcellini, J. M. Lipton   +6 more
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The neuroimmunomodulatory peptide alpha-MSH.

Annals of the New York Academy of Sciences, 2001
Alpha-melanocyte-stimulating hormone (alpha-MSH), a neuroimmunomodulatory peptide of ancient origin, is known to be involved in the control of host responses. In inflammatory cells, in the periphery and within the central nervous system, alpha-MSH modulates the production and action of proinflammatory cytokines.
T, Ichiyama, S, Sato, K, Okada, A, Catania, J M, Lipton   +4 more
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Central administration of alpha-MSH antiserum augments fever in the rabbit

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1986
alpha-Melanocyte-stimulating hormone (alpha-MSH) has a marked antipyretic action when given centrally or peripherally, and the concentration of this peptide within the septal region of the brain increases during fever. To assess the significance of endogenous central alpha-MSH in fever, antiserum was given to rabbits via a cannula implanted in the ...
S T, Shih, O, Khorram, J M, Lipton, S M, McCann   +3 more
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Age-related alterations in the central thermoregulatory responsiveness to alpha-MSH

Journal of Thermal Biology, 2015
Alpha-melanocyte-stimulating-hormone (alpha-MSH) is a neuropeptide that induces weight loss via its anorexigenic and hypermetabolic/hyperthermic effects. Two major public health problems of the human population involving energy balance (i.e. middle-aged obesity and aging cachexia) also appear in other mammals, therefore age-related regulatory ...
I, Rostás, N, Füredi, J, Tenk, A, Mikó, M, Solymár, S, Soós, M, Székely, E, Pétervári, M, Balaskó   +8 more
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Is alpha-MSH deficiency the cause of Alzheimer's disease?

Medical Hypotheses, 1986
The hypothesis is that a functional deficiency of alpha-melanotropin (alpha-MSH) is the primary event in the development of Alzheimer's disease. Beginning with the concept that Alzheimer's disease occurs because of a deficiency of a neurotrophic factor specific for central cholinergic neurons data is then presented to support the hypothesis that alpha ...
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Synthesis of cyclic alpha-MSH peptides

1998
Cyclic lactam analogs of α-melanocyte stimulating hormone (α-MSH) have been shown to be potent agonists in the frog skin bioassay [Al-Obeidi, F. et al., J. Med. Chem., 32 (1989) 2555], demonstrating melanocortin-1 (MC1) receptor activity. We synthesized cyclic α-MSH(1-13) and α-MSH(4-10) lactam analogs.
Schaaper, W.M.M., Adan, R.A.H., Posthuma, T.A., Oosterom, J., Gispen, W.H., Meloen, R.H.   +5 more
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[Modification of alpha-MSH by UVA irradiation of the skin].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1983
On 40 healthy male volunteers with different pigmentation level (Caucasians: skin types I-III, negroes: skin type VI) the basal alpha-MSH-secretion as well as the influence of UV-A-wholebody-irradiation (6 J/cm2) on alpha-MSH-serum concentration were measured.
H, Holzmann, P, Altmeyer, L, Stöhr, G N, Chilf   +3 more
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CSF alpha-MSH in dementia of the Alzheimer type.

Neurology, 1988
We measured CSF alpha-melanocyte stimulating hormone-like immunoreactivity (alpha-MSH-LI) in 35 patients with dementia of the Alzheimer type (DAT) and in 27 healthy control subjects. Mean alpha-MSH-LI concentration was significantly decreased in DAT patients as compared with age-matched controls.
I, Rainero, C, May, J A, Kaye, R P, Friedland, S I, Rapoport   +4 more
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Studies of alpha-MSH-containing nerves in the brain.

Progress in biochemical pharmacology, 1981
alpha-Melanocyte stimulating hormone (alpha-MSH) immunofluorescence was observed in the rat brain using a highly specific and well-characterized antibody. alpha-MSH was contained in the arcuate nucleus cell bodies and in varicose fibers distributed throughout the brain stem. alpha-MSH-containing fibers were present in various nuclei of the hypothalamus,
T L, O'Donohue, D M, Jacobowitz
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Release of LH in response to alpha-MSH administration.

Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia, 1986
The aim of the present study was to determine the effect of alpha-MSH on serum LH in order to obtain some clues about the possible, mechanism by which the peptide modifies gonadotropin secretion. Intact female rats treated with alpha-MSH on diestrus 2 afternoon exhibited an increase in serum LH levels at 18 hr on proestrus and an elevated number of ova
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