Results 41 to 50 of about 8,015 (172)

Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death

Biomolecules
Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis.
Shudan Wang, Francesca Kahale, Amirreza Naderi, Pier Luigi Surico, Jia Yin, Thomas Dohlman, Yihe Chen, Reza Dana   +7 more
doaj   +1 more source

Dimethyl Itaconate Reduces α-MSH-Induced Pigmentation via Modulation of AKT and p38 MAPK Signaling Pathways in B16F10 Mouse Melanoma Cells

Molecules, 2022
Dimethyl itaconate (DMI) exhibits an anti-inflammatory effect. Activation of nuclear factor erythroid 2-related factor 2 (NRF2) is implicated in the inhibition of melanogenesis.
Sungchan Jang, Won-Jae Chi, Seung-Young Kim   +2 more
doaj   +1 more source

Inhibition of Melanogenesis via Passive Immune Targeted Alpha-MSH Binder Polypeptide

Cosmetics
Alpha-melanocyte stimulating hormone (α-MSH) is a hormone that stimulates the formation of melanin, which is responsible for protecting the skin from UV rays.
Se-Hyo Jeong, Hun-Hwan Kim, Abigail Joy D. Rodelas-Angelia, Mark Rickard N. Angelia, Pritam Bhagwan Bhosale, Eun-Hye Kim, Tae-Sung Jung, Mee-Jung Ahn, Gon-Sup Kim   +8 more
doaj   +1 more source

The Value of Technetium-99m Labeled Alpha-Melanocyte- Stimulating Hormone (99mTc-α-MSH) in Diagnosis of Primary and Metastatic Lesions of Malignant Melanoma [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2018
Objective(s): Malignant melanoma is the most lethal type of skincancers with unfavorable prognosis. Alpha-MSH peptide analogues havea high affinity for melanocortine-1 (MC1) receptors on melanocytes overexpressing in malignant melanoma cells.
Saeed Farzanefar, Rahman Etemadi, Mohammad Shirkhoda, Habibollah Mahmoodzadeh, Mostafa Erfani, Babak Fallahi, Mehrshad Abbasi, Narjess Ayati, Arman Hassanzadeh-Rad, Mohammad Eftekhari, Davood Beiki   +10 more
doaj   +1 more source

Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.

PLoS ONE, 2016
Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical ...
Guillaume Le Saux, Laurent Plawinski, Sylvain Nlate, Jean Ripoche, Thierry Buffeteau, Marie-Christine Durrieu   +5 more
doaj   +1 more source

Anti-melanogenesis effect from Wampee fruit pectin via α-MSH/TRY pathway in A375 cells

BMC Complementary Medicine and Therapies, 2022
Background Polysaccharides from wampee have been reported to process various biological activities, while the relationship between structure and bioactivities has been barely addressed.
Weiyu Fu, Xuehua Liao, Qian Zhang, Yuzhen Zhu, Si Mei, Qian Li, Xin Zhou, Xiaojun Li, Hui Luo, Hua Ye, Kefeng Wu   +10 more
doaj   +1 more source

Minocycline Modulation of Alpha-MSH Production by Keratinocytes In vitro

Acta Dermato-Venereologica, 1999
The anti-inflammatory mechanisms of minocycline, an antibiotic used in the treatment of the inflammatory component of acne, are only partially understood. In addition to inflammation due to cytokines (IL-1, IL-6, TNF-alpha, etc.), recent studies have shown that neuropeptide-mediated neurogenic inflammation may play an important role in cutaneous ...
I, Sainte-Marie, I, Tenaud, O, Jumbou, B, Dréno   +3 more
openaire   +3 more sources

Impact of hamstring versus quadriceps tendon graft on thigh muscle strength and surface electromyography activity after anterior cruciate ligament reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare quadriceps tendon (QT) and hamstring tendon (HT) autografts regarding isometric thigh muscle strength, surface electromyography (sEMG) activity and clinical outcomes following anterior cruciate ligament reconstruction (ACLR).
Benjamin Forquignon, Tobias Drenck, Matthias Krause, Ralph Akoto, Karl‐Heinz Frosch, Götz Welsch, Alexander Korthaus, Grégoire Thürig, Dimitris Dalos   +8 more
wiley   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Anti-inflammatory treatment using alpha melanocyte stimulating hormone (α-MSH) does not alter osteoblasts differentiation and fracture healing. [PDF]

BMC Musculoskelet Disord
Background Alpha-melanocyte-stimulating-hormone (α-MSH) has been identified as a new anti-inflammatory treatment compound in rheumatoid arthritis (RA) and other inflammatory diseases.
Graue J, Timmen M, Schmitz K, Kronenberg D, Böhm M, Sivaraj KK, Bixel MG, Stange R.   +7 more
europepmc   +2 more sources