Results 101 to 110 of about 659,948 (302)

Alpha Synuclein Toxicity and Non-Motor Parkinson’s

Cells
Parkinson’s disease (PD) is a common multisystem neurodegenerative disorder affecting 1% of the population over the age of 60 years. The main neuropathological features of PD are the loss of dopaminergic neurons in the substantia nigra pars compacta ...
Gabriella M. Mazzotta, Carmela Conte
doaj   +1 more source

p27Kip1 regulates alpha-synuclein expression

Oncotarget, 2018
Alpha-synuclein (α-SYN) is the main component of anomalous protein aggregates (Lewy bodies) that play a crucial role in several neurodegenerative diseases (synucleinopathies) like Parkinson's disease and multiple system atrophy. However, the mechanisms involved in its transcriptional regulation are poorly understood.
Gallastegui Calvache, Edurne, 1982-, Domuro, Carla, Serratosa i Serdà, Joan, Larrieux, Alejandra, Sin, Laura, Martínez, Jonatan, Besson, Arnaud, Morante Redolat, José Manuel, Orlando, Serena, Aligué i Alemany, Rosa Maria, Fariñas, Isabel, Pujol Sobrevía, María Jesús, Bachs Valldeneu, Oriol   +12 more
openaire   +5 more sources

Alpha-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms

, 2021
No disease-modifying therapy is currently available for Parkinson's disease (PD), the second most common neurodegenerative disease. The long nonmotor prodromal phase of PD is a window of opportunity for early detection and intervention.
Kovacheva, L (15753110), Ruth Musgrove (14745037), Ben-Zvi, D (15753125), Roeper, J (15753131), Goldberg, JA (15753134), Arien-Zakay, H (15753113), Chiu, WH (15753107), Hanani, M (15753128), Yaka, R (15753122), Koprich, JB (15753116), Brotchie, J (15753119)   +10 more
core  

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

How does crowding affect alpha-synuclein conformation?

, 2022
Alpha-synuclein is an intrinsically disordered protein (IDP) located in presynaptic neurons. It has a leading role in the vesicle and neurotransmitter release and regulation.
Sina Heravi, Anand Yethiraj, Valerie Booth   +2 more
core   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Alpha-Synuclein Toxicity in the Early Secretory Pathway: How it Drives Neurodegeneration in Parkinsons Disease

Frontiers in Neuroscience, 2015
Alpha-synuclein is a predominant player in the pathogenesis of Parkinson’s Disease. However, despite extensive study for two decades, its physiological and pathological mechanisms remain poorly understood.
Ting eWang, Ting eWang, Jesse C Hay
doaj   +1 more source

Altered gene expression in the colon of young mice overexpressing alpha-synuclein

, 2020
Background: Evidence supports that Parkinson’s Disease (PD) is a disease of the gut-brain axis. Constipation is prevalent in patients with PD, and mice overexpressing human wild type alpha–synuclein (ASO) have delayed colonic transit in comparison to ...
Charalabos Pothoulakis (357866), Varghese John (317755), Asa Hatami (7113461), Jill Hoffman (741062), Elizabeth Videlock (7377203), Chunni Zhu (7826627)   +5 more
core   +1 more source

Contribution of syndecans to cellular uptake and fibrillation of alpha-synuclein and tau [PDF]

, 2019
Scientific evidence suggests that alpha-synuclein and tau have prion-like properties and that prionlike spreading and seeding of misfolded protein aggregates constitutes a central mechanism for neurodegeneration.
Domonkos, Ildikó, Kodamullil, Alpha Tom, Hudák, Anett, Jósvay, Katalin, Szilák, László, Kusz, Erzsébet, Letoha, Tamás   +6 more
core   +1 more source

Alzheimer's Disease Co‐Pathology and Cognitive Impairment in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objectives Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) share neuropathological features, including tau, amyloid, and TDP‐43 pathology. This study investigated whether AD‐related pathological changes are associated with cognitive impairment ALS. Methods Cerebrospinal fluid (CSF total‐tau, phosphorylated‐tau, beta‐amyloid) and plasma
Elisabeth Kasper, Annaliis Lehto, Alexandra Jürs, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Voigt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Annett Halle, Jochen Herms, Anja Schneider, Stefan Teipel, Johannes Prudlo, Manuela Neumann, Andreas Hermann   +29 more
wiley   +1 more source