Results 161 to 170 of about 1,144,970 (369)

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson\u27s Disease. [PDF]

, 2019
While GM1 may interact with α-synuclein in vitro to inhibit aggregation, the ability of GM1 to protect against α-synuclein toxicity in vivo has not been investigated.
Aras, Radha, Brotchie, Jonathan M., Koprich, James B., Schneider, Jay S., Singh, Vikrant, Williams, Courtney K.   +5 more
core   +1 more source

Simultaneous Inference in General Parametric Models [PDF]

, 2008
Simultaneous inference is a common problem in many areas of application. If multiple null hypotheses are tested simultaneously, the probability of rejecting erroneously at least one of them increases beyond the pre-specified significance level ...
Bates, Bates, Bretz, Bretz, Bullinger, Bönsch, Garcia, Genz, Genz, Genz, Hochberg, Hothorn, Hothorn, Hsu, Marcus, R Development Core Team, Rousseeuw, Salib, Searle, Serfling, Shaffer, Stefanski, Todorov, Tong, Westfall, Westfall, Westfall, Yohai, Zeileis, Zeileis   +29 more
core   +3 more sources

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice [PDF]

, 2012
Pathological studies on Parkinson’s disease (PD) patients suggest that PD pathology progresses from the enteric nervous system (ENS) and the olfactory bulb into the central nervous system.
Arnhold, Mike, Funk, Richard H W, Gille, Gabriele, Marsico, Giovanni, O'Sullivan, Gregory A., Pal, Arun, Pan-Montojo, Francisco, Reichmann, Heinz, Rodrigo-Angulo, Margarita Lucía, Said, Jonas, Schwarz, Mathias, Verbavatz, Jean Marc, Winkler, Clemens   +12 more
core   +2 more sources

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Alpha-synuclein inclusions reduced by PIKfyve inhibition in Parkinson disease cell models

Neurobiology of Disease
Objective: Parkinson's disease (PD) pathophysiology is associated with a progressive loss of dopaminergic neurons in the substantia nigra and accumulation of insoluble inclusions of misfolded alpha-synuclein.
Sara Lucas-Del-Pozo, Giuseppe Uras, Federico Fierli, Veronica Lentini, Sofia Koletsi, Carlos Lazaro-Hernandez, Kai-Yin Chau, Derralynn A. Hughes, Anthony H.V. Schapira   +8 more
doaj   +1 more source

Microglia as modulators of exosomal alpha-synuclein transmission

Cell Death and Disease, 2019
Recent researches regarding to exosomal involvement in alpha-synuclein (α-syn) transmission relating to the pathological process of Parkinson’s disease (PD) have attracted considerable attention. It is highly desirable to make clear the diffusion process
Yun Xia, Guoxin Zhang, Chao Han, Kai Ma, Xingfang Guo, Fang Wan, Liang Kou, Sijia Yin, Ling Liu, Jinsha Huang, N. Xiong, Tao Wang   +11 more
semanticscholar   +1 more source

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. [PDF]

, 2017
Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Esko, Jeffrey D, Ihse, Elisabet, Lawrence, Roger, Masliah, Eliezer, van Wijk, Xander M, Yamakado, Hodaka   +5 more
core   +2 more sources

ATP Hydrolysis by α‐Synuclein Amyloids is Mediated by Enclosing β‐Strand

Advanced Science, EarlyView.
Pathological amyloids have been considered chemically inert until recently. Here it is shown that α‐synuclein amyloids catalyze the hydrolysis of the universal energy molecule, ATP. The cryo‐EM structure of the complex reveals an additional β‐strand (purple) that encloses the ATP‐binding site. Within the cavity, several lysine residues are required for
Lukas Frey, Fiamma Ayelen Buratti, Istvan Horvath, Shraddha Parate, Ranjeet Kumar, Roland Riek, Pernilla Wittung‐Stafshede   +6 more
wiley   +1 more source

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Molecular Neurodegeneration, 2012
Background Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of sporadic and familial Parkinson’s disease (PD) as well as dementia with Lewy bodies, with recent evidence implicating oligomeric and pre-fibrillar forms of αsyn ...
Danzer Karin M, Kranich Lisa R, Ruf Wolfgang P, Cagsal-Getkin Ozge, Winslow Ashley R, Zhu Liya, Vanderburg Charles R, McLean Pamela J   +7 more
doaj   +1 more source