Results 161 to 170 of about 31,365 (260)

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source

Interplay between lipid droplets and alpha-synuclein: implication in Parkinson's disease pathogenesis. [PDF]

Front Mol Neurosci
Idi W, Sheta R, Oueslati A.
europepmc   +1 more source

Clinical Trial Highlights: Targeting Alpha-Synuclein

Journal of Parkinson's Disease, 2019
Kevin, McFarthing, Tanya, Simuni
openaire   +3 more sources

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source

Inhibition of de novo ceramide synthesis mitigates alpha-synuclein pathology in a Parkinson's disease mouse model. [PDF]

NPJ Parkinsons Dis
Lee E, Park MY, Park M, Kim NY, Wei S, Hwang N, Ryu D, Ryu H, Park D, Lee G, Oh CM.   +10 more
europepmc   +1 more source

Disturbing dreams and dementia incidence across diverse cohort studies: A COSMIC collaboration study

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Distressing dreams were previously reported to predict future all‐cause dementia among predominantly white US participants aged 79–89 years, particularly in men. We investigated whether disturbing dreams (nightmares and bad dreams) were associated with all‐cause and Alzheimer dementia (AD) among individuals aged 60–89 years from diverse ...
Darren M. Lipnicki, Ashleigh S. Vella, Erico Castro‐Costa, Sergio Luis Blay, Maria Fernanda Lima‐Costa, Karen Ritchie, Elena Rolandi, Annalisa Davin, Michele Rossi, Ki Woong Kim, Ji Won Han, Dae Jong Oh, Ding Ding, Qianhua Zhao, Xiaowen Zhou, Yen‐Ching Chen, Jen‐Hau Chen, Perminder S. Sachdev, for Cohort Studies of Memory in an International Consortium (COSMIC)   +18 more
wiley   +1 more source

Enteric glia, neuropeptides, and Parkinson's: impacts of calcitonin gene-related peptide on gut alpha synuclein. [PDF]

Am J Physiol Gastrointest Liver Physiol
Templeton HN, Lanser TB, Tobet SA, Schwerdtfeger LA.   +3 more
europepmc   +1 more source

α‐Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Giulia Tomagra, Anthony Battaglia, Claudio Franchino, Sara Bonzano, Federico Picollo, Giuseppe Chiantia, Antonio de Iure, Paolo Calabresi, Barbara Picconi, Emilio Carbone, Silvia De Marchis, Andrea Marcantoni, Valentina Carabelli   +12 more
wiley   +1 more source

Cholesterol modulates vesicle clustering mediated by alpha-synuclein in a nonlinear fashion. [PDF]

Biophys Rep
Tyoe O, Aryal C, Diao J.
europepmc   +1 more source

Serum p‐tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder

Annals of Neurology, Volume 99, Issue 4, Page 912-921, April 2026.
Objective Assess the performance of serum phosphorylated tau 217 (p‐tau217) and neurofilament light chain (NfL) in predicting risk of cognitive impairment or phenoconversion to dementia in individuals with iRBD. Methods We measured serum p‐tau217 and NfL levels by electrochemiluminescence across 4 polysomnographically confirmed iRBD cohorts (n = 300 ...
Shijun Yan, Anis Sahoo, Tanja Zerenner, Kenneth Marek, Michael Sommerauer, Wolfgang Oertel, Michele T. Hu, George K. Tofaris   +7 more
wiley   +1 more source