Results 181 to 190 of about 1,144,970 (369)
Accurate Generation of Conformational Ensembles for Intrinsically Disordered Proteins with IDPFold
Advanced Science, EarlyView.In brief: IDPFold predicts the conformational ensembles of intrinsically disordered proteins (IDPs) from their amino acid sequences. The atomic structures generated by IDPFold offer crucial insights into the intricate relationship between IDP structures and their diverse biological functions.2 Abstract Intrinsically disordered proteins (IDPs) play ...
Junjie Zhu +10 more
wiley +1 more source
The G209A mutation in the alpha-synuclein gene in Brazilian families with Parkinson's disease [PDF]
, 2001 Hélio Afonso Ghizoni Teive +10 more
openalex +1 more source
Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives
Advanced Science, EarlyView.Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley +1 more source
Disease modifying therapy for multiple system atrophy – Parkinsonian Type [PDF]
, 2017 BACKGROUND: Multiple System Atrophy –Parkinsonian Type (MSA-P) is a rare, rapidly progressive neurodegenerative disease without any current treatment.
Dwyer, Sean Sullivan
core
Oligomerisation of Alpha-Synuclein at Physiological Concentrations [PDF]
Biophysical Journal, 2014 Alpha-synuclein is a small intracellular protein naturally abundant in the brain at low-micromolar concentrations. Its fibrillar aggregates are the major constituents of intracellular inclusions, known as Lewy bodies, which are the pathological hallmarks of Parkinson disease and related neurodegenerative disorders.
openaire +2 more sources
Nanozymes for Non‐Neoplastic Diseases: Catalytic Therapy Redefined
Aggregate, EarlyView.Non‐neoplastic diseases pose a significant health burden. Nanozymes, enzyme‐like nanomaterials, offer promising strategies for regulating oxidative stress and inflammation. This review explores their development, structure–function relationships, and therapeutic potential, with a focus on precision medicine through targeted delivery and multimodal ...
Ling Mei +8 more
wiley +1 more source
Bioinspired Engineering beyond Homeostasis
Advanced Intelligent Systems, EarlyView.This perspective article introduces systems biology as the unifying theoretical framework behind bioinspired engineering. As an example, it explores how disruptions in multiscale biological systems, associated with pathological states, can be viewed as localized failure modes of biological cooperation showing emergent advantages that can inspire ...
Rosalia Moreddu
wiley +1 more source
Interaction between parkin and alpha‐synuclein [PDF]
, 2002 Hideki Shimura +5 more
openalex +1 more source
Alpha-synuclein and Parkinson disease
Neural Regeneration Research, 2007 Abstract Objective To review the recent progresses on the studies ofa-synuclein in the pathogenesis of Parkinson disease (PD) and look into the perspective ofa-synuclein as a new therapy target. Data sources To search the literatures on the progresses of PD studies, especially on the structure, gene expression of a-synuclein and the pathogenesis
openaire +2 more sources
Turning Slowly Predicts Future Diagnosis of Parkinson's Disease: A Decade‐Long Longitudinal Analysis
Annals of Neurology, EarlyView.Objective Wearable technology allows accurate measurement of turning while walking, with cross‐sectional studies indicating that difficulty turning presents even in preclinical phases of Parkinson's disease. The aim of our study was to quantify rate of change of turning performance in a cohort of older adults, and test whether turning decline can ...
Morad Elshehabi +9 more
wiley +1 more source