Results 191 to 200 of about 1,144,970 (369)
Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies [PDF]
, 2003 Takashi Ishizawa +4 more
openalex +1 more source
Annals of Neurology, EarlyView.Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang +10 more
wiley +1 more source
Pathophysiology of alpha‐synuclein: Molecular mechanisms of neurodegenerative diseases [PDF]
, 2004 openalex +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala +4 more
wiley +1 more source
Zebrafish: A Versatile and Powerful Model for Biomedical Research
BioEssays, EarlyView.Zebrafish are vital for advancing precision medicine, offering a genetically tractable and optically transparent vertebrate model with strong genetic homology to humans. They enable rapid and cost‐effective disease modeling and drug discovery, accelerating insights into cardiovascular, neurological, metabolic, and oncological disorders through gene ...
Sundus Siddiqui +3 more
wiley +1 more source
The aggregation of alpha‐synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy [PDF]
, 2006 Melanie Gérard +6 more
openalex +1 more source
Biochemistry and Molecular Biology Education, Volume 53, Issue 2, Page 209-217, March/April 2025.Abstract We created a novel laboratory experience where undergraduate students explore the techniques used to study protein misfolding, unfolding, and aggregation. Despite the importance of protein misfolding and aggregation diseases, protein unfolding is not typically explored in undergraduate biochemistry laboratory classes.
Alison Bates +2 more
wiley +1 more source
P3-311: Sumo modification of natively unfolded proteins tau and alpha-synuclein [PDF]
, 2006 Véronique Dorval, Paul E. Fraser
openalex +1 more source
ChemBioChem, EarlyView.Binding studies of α‐synuclein (αS) fibril ligands using photo‐crosslinking mass spectrometry and Förster resonance energy transfer show that the multiple system atrophy (MSA)‐selective lead, HY‐215, interacts with the αS C‐terminus, unlike Parkinson's disease (PD)‐selective lead, M503. Thus, often‐ignored interactions with the disordered regions of αS
Kyle D. Shaffer +8 more
wiley +1 more source
Structure and dynamics of the aggregation mechanism of the Parkinson´s disease-associated protein alpha-synuclein [PDF]
, 2006 Carlos W. Bertoncini
openalex +1 more source