Results 111 to 120 of about 28,973 (151)
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Hydrops Fetalis with Alpha Thalassemia
New England Journal of Medicine, 1967HYDROPS fetalis associated with hemoglobin Barts is believed to represent the homozygous state of α thalassemia. Ten cases occurring in Chinese families in Indonesia, Malaya and Hong Kong, 1 in a Greek Cypriot family and 1 in a Filipino family, have been described.1 2 3 4 5 6 7 Recently, several more cases have been seen among Chinese in Hong Kong.8 We
Y W, Kan, A, Allen, L, Lowenstein
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Annales de biologie clinique, 1995
alpha-Thalassaemias are probably the most common genetic disorder worldwide. alpha-Thalassaemias are haemolytic anaemias resulting from inherited deficient synthesis of alpha-globin chains. In this paper, the classification and nomenclature of alpha-thalassaemias are developed. Procedures to ensure the laboratory diagnosis are explained.
J Y, Peltier, C, Sayada, R, Girot
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alpha-Thalassaemias are probably the most common genetic disorder worldwide. alpha-Thalassaemias are haemolytic anaemias resulting from inherited deficient synthesis of alpha-globin chains. In this paper, the classification and nomenclature of alpha-thalassaemias are developed. Procedures to ensure the laboratory diagnosis are explained.
J Y, Peltier, C, Sayada, R, Girot
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Molecular genetics of alpha thalassemia
Medical Hypotheses, 1989Linked duplicate genes in Chromosome 16 condition the production not only of alpha-globin chains in the Hemoglobin A (HbA) molecule, but also of the varied forms of alpha thalassemia in human subjects. Null allelism, not gene deletion, exists at these gene loci.
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[Alpha thalassemia in Macedonia].
Bilten za hematologiju i transfuziju, 1983The frequency of alpha thalassemia in SR Macedonia was determined with studies of Hb Bart's in 1.140 newborn babies. Hb Bart's was found in 83 infants. Distribution of the levels of Hb Bart's in these neonates, as determined by column chromatography on CM Sephadex, was trimodal. The mean values for Hb Bart's in the three groups were 0.5% (SD = 0.22), 1.
G, Efremov +3 more
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THE MOLECULAR AND HEMATOLOGICAL HETEROGENEITY OF ALPHA THALASSEMIA
Australian and New Zealand Journal of Medicine, 1984Abstract:A study of genotypes in ? thalassemia and their corresponding hematological phenotypes has shown that α+ thalassemia is the most frequent type encountered in a Sydney population. Phenotypes of heterozygous α+ thalassemia (αα/−α) in adults or children differ little from normal and so the disorder is difficult to identify. In contrast, Hb Bart's
R J, Trent +3 more
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Advances in the treatment of alpha-thalassemia
Blood Reviews, 2012Alpha (α)-thalassemia represents a group of recessively inherited hemoglobin disorders marked by deficient or absent synthesis of 1 to all 4 of the α-globin genes. Inactivation of 3 α-globin genes--either by deletional or nondeletional mutations--results in hemoglobin H (Hb H) disease.
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Alpha-Thalassemia as Cause of Nonimmunological Hydrops
Archives of Pediatrics & Adolescent Medicine, 1965IN 1955 A Filipino couple had a premature fetus with clinical and pathological features of hydrops fetalis, but no iso-immune basis for the disease could be documented. The 1962 report of Lie-Injo and her associates in Indonesia describing homozygous α-thalassemia as a cause of nonimmunological hydrops fetalis1prompted reinvestigation of this family ...
H A, PEARSON +2 more
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Erythropoietin Levels in Heterozygous Alpha-Thalassemia
Acta Haematologica, 2009In guinea pig bone marrow cultures with heterozygous α-thalassemic serum, 59Fe uptake values are elevated above iron values of cultures with serum of normal subjects. These results show that erythropoietin (EP) activity values in heterozygous α-thalassemia are comparable to those previously observed by ourselves in heterozygous β-thalassemia despite of
M, Vedovato +5 more
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Effects of Alpha Thalassemia on Mouse Development
Differentiation, 1980Matings were made between (1) normal mice, (2) heterozygous alpha thalassemic females and normal males, and (3) heterozygous alpha thalassemic mice to produce litters of (1) normal mice, (2) normal and heterozygous alpha thalassemic mice, and (3) normal, heterozygous, and homozygous alpha thalassemic mice, respectively, in order to determine what ...
R A, Popp, B S, Bradshaw, L C, Skow
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Alpha-thalassemia in Papua New Guinea
Human Genetics, 1986A study of the distribution of alpha-thalassemia in Papua New Guinea (PNG) was carried out by DNA analysis. A total of 664 DNA samples were screened for alpha-thalassemia 2 and alpha-thalassemia 1 caused respectively by either deletion of one or both of the duplicated alpha-globin genes.
Yenchitsomanus, P. +6 more
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