Results 11 to 20 of about 1,145,402 (246)
Definitions, 2020 Alpha thalassemia major (ATM) is inherited in an autosomal recessive manner. This means that two non-functioning genes have to be passed to the fetus from each parent, resulting in loss of function of all four alpha globin genes in the fetus. A pregnancy
Alpha Thalassemia, Kevin H.M. Kuo
semanticscholar +5 more sources
Newborn Screening Practices and Alpha-Thalassemia Detection - United States, 2016. [PDF]
MMWR Morb Mortal Wkly Rep, 2020 Alpha-thalassemia comprises a group of inherited disorders in which alpha-hemoglobin chain production is reduced. Depending on the genotype, alpha-thalassemia results in moderate to profound anemia, hemolysis, growth delays, splenomegaly, and increased ...
Bender MA +10 more
europepmc +2 more sources
Deletional Alpha-Thalassemia Alleles in Amazon Blood Donors
Advances in Hematology, 2020 Alpha-thalassemia is highly prevalent in the plural society of Brazil and is a public health problem. There is limited knowledge on its accurate frequency and distribution in the Amazon region.
Fernanda Cozendey Anselmo +7 more
doaj +2 more sources
Hematological analysis of alpha-thalassemia: A single-center, retrospective clinical study. [PDF]
PLoS ONEObjectivesTo determine the optimal cutoffs of the three indicators (MCV, MCH and HbA2) for alpha-thalassemia screening and to evaluate the validity of these indicators in Fujian Province, China.MethodsWe conducted a retrospective analysis on the results ...
Lin Zheng +7 more
doaj +2 more sources
Genetic Analysis of Alpha-Thalassemia Mutations in Thi-Gar Province, Iraq [PDF]
Archives of Razi Institute, 2022 The prevalence of alpha-thalassemia as a major health problem in the south of Iraq has highlighted the necessity of investigations and screening of patients with thalassemia.
A. H Odah Al-Musawi +2 more
doaj +2 more sources
Impact of genotype on endocrinal complications of Children with Alpha-thalassemia in China
Scientific Reports, 2017 Alpha-thalassemia occurs with high frenquency in China. Four common α-globin gene deletion mutations (–SEA, -α3.7, and -α4.2, Haemoglobin Constant Spring (CS) mutation) were identified in Chinese patients.
Hong-Cheng Luo +4 more
doaj +2 more sources
Turkish Journal of Hematology, 2015 INTRODUCTION: Alpha thalassemia syndromes are caused by mutations on one or more of the four α-globin genes. Mutations could be either more commonly deletional or non-deletional. As some deletions (3.7 and 4.2) cause α+-thalassemia, some cause (
Zeynep Karakaş +11 more
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Third-generation sequencing identified a novel complex variant in a patient with rare alpha-thalassemia [PDF]
BMC PediatricsBackground Thalassemias represent some of the most common monogenic diseases worldwide and are caused by variations in human hemoglobin genes which disrupt the balance of synthesis between the alpha and beta globin chains.
Cong Zhou +5 more
doaj +2 more sources
Alpha thalassemia and alpha-MRE haplotypes in Uruguayan patients with microcytosis and hypochromia without anemia [PDF]
Genetics and Molecular Biology, 2021 Alpha thalassemia is the most common genetic disorder across the world, being the α-3.7 deletion the most frequent mutation. In order to analyze the spectrum and origin of alpha thalassemia mutations in Uruguay, we obtained a sample of 168 unrelated ...
Ana María Soler +7 more
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Alpha-Thalassemia: Diversity of Clinical Phenotypes and Update on the Treatment
Thalassemia Reports, 2022 One of the more common single-gene disorders worldwide is α-thalassemia, carriers of which are found at variable frequencies (>1%) across all tropical and subtropical countries.
D. Songdej, S. Fucharoen
semanticscholar +1 more source