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Molecular genetics of alpha thalassemia
Medical Hypotheses, 1989Linked duplicate genes in Chromosome 16 condition the production not only of alpha-globin chains in the Hemoglobin A (HbA) molecule, but also of the varied forms of alpha thalassemia in human subjects. Null allelism, not gene deletion, exists at these gene loci.
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Alpha-thalassemia in Papua New Guinea
Human Genetics, 1986A study of the distribution of alpha-thalassemia in Papua New Guinea (PNG) was carried out by DNA analysis. A total of 664 DNA samples were screened for alpha-thalassemia 2 and alpha-thalassemia 1 caused respectively by either deletion of one or both of the duplicated alpha-globin genes.
Yenchitsomanus, P. +6 more
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Erythropoietin Levels in Heterozygous Alpha-Thalassemia
Acta Haematologica, 1986In guinea pig bone marrow cultures with heterozygous alpha-thalassemic serum, 59Fe uptake values are elevated above iron values of cultures with serum of normal subjects. These results show that erythropoietin (EP) activity values in heterozygous alpha-thalassemia are comparable to those previously observed by ourselves in heterozygous beta-thalassemia
M, Vedovato +5 more
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Intrauterine therapy for homozygous $alpha;-thalassemia
Obstetrics & Gynecology, 1995Alpha-thalassemia is one of the most common genetic disorders in the world and is becoming more common in the United States with the increase in immigration of susceptible populations. This disease has been stated previously to be incompatible with extrauterine life.A Filipino woman with a prior loss due to hemoglobin Bart's underwent prenatal ...
S, Carr +4 more
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Alpha-thalassemia in Thailand.
Hemoglobin, 1989The alpha-thalassemia syndromes are remarkable both for their phenotypic diversity and for their different clinical severity. They are associated with variable degrees of alpha-chain deficits; the clinical manifestations range from asymptomatic cases with normal hematologic findings to the totally lethal Hb Bart's hydrops fetalis syndrome.
P, Winichagoon +4 more
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[alpha-thalassemia among Danish immigrants].
Ugeskrift for laeger, 2002alpha-thalassaemia is the most common hereditary anaemia in the world. The majority of Danish immigrants come from countries, where the prevalence of alpha-thalassaemia is high. The aim of this study was to evaluate its frequency in Danish immigrants.Over a year, all samples sent for haemoglobin analysis to our institution from patients with an MCV ...
Henrik S, Birgens +2 more
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The Interaction of Alpha-Thalassemia and Homozygous Sickle-Cell Disease
New England Journal of Medicine, 1982Douglas R Higgs
exaly