Results 211 to 220 of about 1,145,402 (246)
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Clinical Laboratory, 2021
BACKGROUND The two major causes of microcytic anemia are iron deficiency and thalassemia. In clinical practice, in some cases, differentiation of microcytic and hypochromic anemia become difficult on the basis of traditional red cell parameters.
M. Saboor
semanticscholar +1 more source
BACKGROUND The two major causes of microcytic anemia are iron deficiency and thalassemia. In clinical practice, in some cases, differentiation of microcytic and hypochromic anemia become difficult on the basis of traditional red cell parameters.
M. Saboor
semanticscholar +1 more source
Hydrops Fetalis with Alpha Thalassemia
New England Journal of Medicine, 1967HYDROPS fetalis associated with hemoglobin Barts is believed to represent the homozygous state of α thalassemia. Ten cases occurring in Chinese families in Indonesia, Malaya and Hong Kong, 1 in a Greek Cypriot family and 1 in a Filipino family, have been described.1 2 3 4 5 6 7 Recently, several more cases have been seen among Chinese in Hong Kong.8 We
Y W, Kan, A, Allen, L, Lowenstein
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Pediatric Blood & Cancer, 2019
Our objective was to investigate the combined and differential effects of alpha‐thalassemia –3.7 kb deletion and HbF‐promoting quantitative trait loci (HbF‐QTL) in Senegalese hydroxyurea (HU)‐free children and young adults with sickle cell anemia (SCA).
Fatou Guèye Tall +12 more
semanticscholar +1 more source
Our objective was to investigate the combined and differential effects of alpha‐thalassemia –3.7 kb deletion and HbF‐promoting quantitative trait loci (HbF‐QTL) in Senegalese hydroxyurea (HU)‐free children and young adults with sickle cell anemia (SCA).
Fatou Guèye Tall +12 more
semanticscholar +1 more source
Alpha thalassemia allelic frequency in Lebanon
Pediatric Blood & Cancer, 2015BackgroundHemoglobinopathies are the most common reported monogenic disorders worldwide. It is well established that Mediterranean and Arab countries are high risk areas for thalassemia in general, and for alpha thalassemia in particular. Reports of alpha thalassemia gene mutations from the Lebanese population are limited.ProcedureWe investigated the ...
C. Farra +8 more
semanticscholar +3 more sources
[Alpha thalassemia in Macedonia].
Bilten za hematologiju i transfuziju, 1983The frequency of alpha thalassemia in SR Macedonia was determined with studies of Hb Bart's in 1.140 newborn babies. Hb Bart's was found in 83 infants. Distribution of the levels of Hb Bart's in these neonates, as determined by column chromatography on CM Sephadex, was trimodal. The mean values for Hb Bart's in the three groups were 0.5% (SD = 0.22), 1.
G, Efremov +3 more
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Annales de biologie clinique, 1995
alpha-Thalassaemias are probably the most common genetic disorder worldwide. alpha-Thalassaemias are haemolytic anaemias resulting from inherited deficient synthesis of alpha-globin chains. In this paper, the classification and nomenclature of alpha-thalassaemias are developed. Procedures to ensure the laboratory diagnosis are explained.
J Y, Peltier, C, Sayada, R, Girot
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alpha-Thalassaemias are probably the most common genetic disorder worldwide. alpha-Thalassaemias are haemolytic anaemias resulting from inherited deficient synthesis of alpha-globin chains. In this paper, the classification and nomenclature of alpha-thalassaemias are developed. Procedures to ensure the laboratory diagnosis are explained.
J Y, Peltier, C, Sayada, R, Girot
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Molecular genetics of alpha thalassemia
Medical Hypotheses, 1989Linked duplicate genes in Chromosome 16 condition the production not only of alpha-globin chains in the Hemoglobin A (HbA) molecule, but also of the varied forms of alpha thalassemia in human subjects. Null allelism, not gene deletion, exists at these gene loci.
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Alpha-thalassemia in Papua New Guinea
Human Genetics, 1986A study of the distribution of alpha-thalassemia in Papua New Guinea (PNG) was carried out by DNA analysis. A total of 664 DNA samples were screened for alpha-thalassemia 2 and alpha-thalassemia 1 caused respectively by either deletion of one or both of the duplicated alpha-globin genes.
Yenchitsomanus, P. +6 more
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Erythropoietin Levels in Heterozygous Alpha-Thalassemia
Acta Haematologica, 1986In guinea pig bone marrow cultures with heterozygous alpha-thalassemic serum, 59Fe uptake values are elevated above iron values of cultures with serum of normal subjects. These results show that erythropoietin (EP) activity values in heterozygous alpha-thalassemia are comparable to those previously observed by ourselves in heterozygous beta-thalassemia
M, Vedovato +5 more
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Intrauterine therapy for homozygous $alpha;-thalassemia
Obstetrics & Gynecology, 1995Alpha-thalassemia is one of the most common genetic disorders in the world and is becoming more common in the United States with the increase in immigration of susceptible populations. This disease has been stated previously to be incompatible with extrauterine life.A Filipino woman with a prior loss due to hemoglobin Bart's underwent prenatal ...
S, Carr +4 more
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