Results 51 to 60 of about 1,861,986 (269)

Single-Use Technology Today – A Cornucopia of Applications

CHIMIA
Whether for classic biologics or advanced therapy medicinal products (ATMPs), laboratory applications, small-scale or large-scale productions, single-use technology (SUT), and its associated consumables are used everywhere.
Diego R. Schmidhalter, Dieter Eibl, Regine Eibl   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

XEN Glaucoma Implant with Mitomycin C 1-Year Follow-Up: Result and Complications

Journal of Ophthalmology, 2017
Purpose. To evaluate gel microstent (XEN, Aquesys, Inc) for treatment of primary open angle glaucoma (POAG). Methods. In this prospective interventional study, 13 eyes with POAG underwent XEN implantation with subconjunctival mitomycin-C.
Ahmed Galal, Alper Bilgic, Rasha Eltanamly, Amr Osman   +3 more
doaj   +1 more source

The Impact of Climate Change on Biblical Interpretation and Theology [PDF]

E-Journal of Humanities, Arts and Social Sciences
This study investigates how climate change influences biblical interpretation and theology, with the aim of aligning ecological concerns with scriptural and doctrinal perspectives. Key goals include examining reinterpretations of scripture, assessing the
Richard Osei Akoto
doaj   +1 more source

Lysosomal alpha-mannosidase and alpha-mannosidosis

Frontiers in Bioscience, 2017
Lysosomal alpha-mannosidase with acidic pH optimum is ubiquitous in human tissues where is expressed in two major forms, A and B that are the product of a single gene located on chromosome 19. Mutations in the gene encoding for alpha-mannosidase cause alpha- mannosidosis, an autosomal recessive disease, resulting in the accumulation of unprocessed ...
PACIOTTI, SILVIA, CODINI, Michela, TASEGIAN, ANNA, CECCARINI, MARIA RACHELE, CATALDI, SAMUELA, ARCURI, Cataldo, FIORETTI, Bernard, ALBI, Elisabetta, BECCARI, Tommaso   +8 more
openaire   +3 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Understanding Diabetes Remission

Apollo Medicine
Background and Aim: Diabetes is a chronic metabolic disorder with increasing prevalence and mortality. Historically it has been considered as a controllable but incurable disease.
Kumaravel Velayutham, Gomathi Panneerselvam, Balaji Ramanathan   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Thyroid lobectomy in childhood: a case study of papillary carcinoma

Mìžnarodnij Endokrinologìčnij Žurnal
Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer in children, although its presentation in this age group remains rare. PTC, despite having a good prognosis, can present more aggressively in children than in adults.
Teuta Mulla Goga, Afrim Zeqiraj, Dafina Zeqiraj   +2 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source