Results 151 to 160 of about 5,544 (202)

Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness. [PDF]

open access: yesMol Psychiatry
Yang S   +12 more
europepmc   +1 more source

Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia

Expert Opinion on Therapeutic Targets, 2013
Schizophrenia is a profoundly debilitating disease that represents not only an individual, but a societal problem. Once characterized solely by the hyperactivity of the dopaminergic system, therapies directed to dampen dopaminergic neurotransmission were developed.
Tanya L Wallace, Daniel Bertrand
exaly   +4 more sources

Alpha7 nicotinic acetylcholine receptors in lung inflammation and carcinogenesis: Friends or foes?

Journal of Cellular Physiology, 2019
The lung tissue expresses the cholinergic system including nicotinic acetylcholine receptors (nAChRs) which included in many physiologic and pathologic processes. Mounting evidence revealed that these receptors have important roles in lung carcinogenesis
Khalil Hajiasgharzadeh   +2 more
exaly   +2 more sources

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease.

Biochemical Pharmacology, 2011
A promising drug target currently under investigation to improve cognitive deficits in neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine receptor (α7nAChR). Improving cognitive impairments in diseases such as Alzheimer's (AD) and schizophrenia remains a large unmet medical need, and the α7nAChR has many ...
T. Wallace, R. Porter
semanticscholar   +3 more sources

Behavioral effects of PNU-282987, an alpha7 nicotinic receptor agonist, in mice

Behavioural Brain Research, 2011
The cholinergic system is closely related to learning and memory processes, and its neurodegeneration seems to be involved in neurodegenerative and neuropsychiatric cognitive disorders in the elderly. Alpha7 nicotinic acetylcholine receptors (nAChRs) have recently been shown to mediate neuroprotection and enhance cognitive performance in a variety of ...
Margarita Torrente, JOSÉ L Domingo
exaly   +4 more sources

Application of Alpha7 Nicotinic Acetylcholine Receptor Agonists in Inflammatory Diseases: An Overview

Pharmaceutical Research, 2011
Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as ...
M. Marrero   +3 more
semanticscholar   +3 more sources

The alpha7 integrin subunit in astrocytes promotes endothelial blood-brain barrier integrity.

Development, 2023
The blood-brain barrier (BBB) is a vascular endothelial cell boundary that partitions the circulation from the central nervous system to promote normal brain health.
Zhihua Chen   +6 more
semanticscholar   +1 more source

Berberine Ameliorates Glucose Metabolism in Diabetic Rats through the alpha7 Nicotinic Acetylcholine Receptor-Related Cholinergic Anti-Inflammatory Pathway

Planta Medica, 2021
Berberine is an isoquinoline derivative alkaloid extracted from Chinese herbs. Recent studies have demonstrated the therapeutic effect of berberine on glucose metabolic disorders. However, its specific mechanism is still unclear.
Ding-kun Wang   +8 more
semanticscholar   +1 more source

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