Results 41 to 50 of about 14,550 (189)

SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort [PDF]

, 2012
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of respiratory health remains controversial.
Margaret Gerbase, Nicole M Probst-Hensch, Zorzetto Michele, Zorzetto, M., F. Kronenberg, P. Bridevaux, Ottaviani, S., LUISETTI, MAURIZIO, Zemp, E., N. M. Probst Hensch, Elisabeth Zemp (142900), Erich W Russi, Gian-Andri Thun (142891), Gerbase Margaret, Russi Erich W., Gian-Andri Thun, Thierry Rochat, E. Zemp, FERRAROTTI, ILARIA, Florian Kronenberg (87557), Maurizio Luisetti (142908), G. Thun, Nicole M. Probst-Hensch (110284), Michele Zorzetto (142902), Russi, E. W., Medea Imboden, Stefania Ottaviani, Ilaria Ferrarotti (142893), Pierre-Olivier Bridevaux, Kronenberg Florian, Florian Kronenberg, Ferrarotti, I., Bridevaux Pierre-Olivier, Luisetti Maurizio, S. Ottaviani, Erich W. Russi (142906), Ferrarotti Ilaria, Stefania Ottaviani (142904), Thun Gian-Andri, Michele Zorzetto, E. W. Russi, Gerbase, M., Bridevaux, P. O., Pierre-Olivier Bridevaux (142898), Rochat, T., T. Rochat, Thierry Rochat (110261), Thun, G. A., M. Gerbase, Ilaria Ferrarotti, Margaret Gerbase (142896), Elisabeth Zemp, Maurizio Luisetti, Imboden, M., Medea Imboden (110145), Imboden Medea, M. Zorzetto, Rochat Thierry, Kronenberg, F., Probst-Hensch, N. M., M. Imboden, Probst-Hensch Nicole M., Luisetti, M., Ottaviani Stefania, Zemp Elisabeth   +64 more
core   +1 more source

Supplementary appendix: Alpha-1 Antitrypsin Deficiency-Associated Panniculitis.

, 2021
Supplementary appendix to "Alpha-1 Antitrypsin Deficiency-Associated Panniculitis"
Franciosi, A (via Mendeley Data)
core   +1 more source

Successful Outcome and Biliary Drainage in an Infant with Concurrent Alpha-1-Antitrypsin Deficiency and Biliary Atresia

Case Reports in Surgery, 2017
We describe the rare instance of concomitant biliary atresia and alpha-1-antitrypsin deficiency and the first documented successful portoenterostomy in this scenario.
Andrew W. Wang, Kimberly Newton, Karen Kling   +2 more
doaj   +1 more source

The first report of two cases of fatal liver injury due to anti-tuberculosis drugs in the presence of alpha-1 antitrypsin deficiency

International Journal of Mycobacteriology, 2017
Tuberculosis (TB) is a major global health problem. Awareness of liver injury due to anti-TB therapy is vital because fulminant hepatic failure is a devastating and often fatal condition without liver transplantation.
Shahram Habibzadeh, Jafar Mohammad Shahi, Hassan Ghobadi, Nasrollah Maleki   +3 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Difficulties in diagnosing and managing a patient with alpha-1-antitrypsin deficiency (clinical case)

Клинический разбор в общей медицине
Alpha-1-antitrypsin deficiency (A1ATD) is a rare hereditary disorder that most commonly manifests in adults by damage to the respiratory system. The disease prevalence varies across different populations and has not been fully established, while the ...
Oleg M. Uryasev, Lyudmila V. Korshunova, Kirill O. Slabachkov, Alexandra V. Solovieva, Maria A. Rodionova   +4 more
doaj   +1 more source

Augmentation therapy with human alpha-1-proteinase inhibitor reduces exacerbations in patient with bronchiectasis and alpha-1-antitrypsin deficiency

Respiratory Medicine Case Reports, 2022
Alpha-1-antitrypsin deficiency (AATD) is a rare cause of noncystic fibrosis (CF) bronchiectasis. The benefits of augmentation therapy in patients with chronic obstructive pulmonary disease (COPD) and pulmonary emphysema are well established.
Emanuel Buck, Maria Ada Presotto, Judith Brock, Kai Schlamp, Martina Veith, Felix J.F. Herth, Franziska Christina Trudzinski   +6 more
doaj   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Testing Alpha-1 Antitrypsin Deficiency in Black Populations

Advances in Respiratory Medicine, 2023
Alpha-1 antitrypsin (AAT) deficiency (AATD) is an under-recognized hereditary disorder and a significant cause of chronic obstructive pulmonary disease (COPD), a disease that contributes to global mortality.
Pascale Lafortune, Kanza Zahid, Magdalena Ploszaj, Emilio Awadalla, Tomás P. Carroll, Patrick Geraghty   +5 more
doaj   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source