Results 91 to 100 of about 3,975,342 (333)

Temperature Profiles in Hamiltonian Heat Conduction

, 2004
We study heat transport in the context of Hamiltonian and related stochastic models with nearest-neighbor coupling, and derive a universal law for the temperature profiles of a large class of such models.
Bonetto F., Eckmann J.-P., Fourier J. B. J., Hirschfelder J., J.-P Eckmann, L.-S Young, Li B., Lorentz H., Prosen T.   +8 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The interplay of intrinsic disorder and macromolecular crowding on {\alpha}-synuclein fibril formation

, 2016
{\alpha}-synuclein ({\alpha}-syn) is an intrinsically disordered protein which is considered to be one of the causes of Parkinson's disease. This protein forms amyloid fibrils when in a highly concentrated solution.
Kikuchi, Macoto, Shirai, Nobu C.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

New experimental limits on the alpha decays of lead isotopes

, 2012
For the first time a PbWO4 crystal was grown using ancient Roman lead and it was run as a cryogenic detector. Thanks to the simultaneous and independent read-out of heat and scintillation light, the detector was able to discriminate beta/gamma ...
Beeman, J. W., Bellini, F., Cardani, L., Casali, N., Di Domizio, S., Fiorini, E., Gironi, L., Nagorny, S. S., Nisi, S., Orio, F., Pattavina, L., Pessina, G., Piperno, G., Pirro, S., Previtali, E., Rusconi, C., Tomei, C., Vignati, M.   +17 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Calculation of alpha particle single-event spectra using a neural network

Frontiers in Oncology
IntroductionA neural network was trained to accurately predict the entire single-event specific energy spectra for use in alpha-particle microdosimetry calculations.MethodsThe network consisted of 4 inputs and 21 outputs and was trained on data ...
Layth Alkhani, Jason P. Luce, Pablo Mínguez Gabiña, John C. Roeske   +3 more
doaj   +1 more source

Wetting Transitions Displayed by Persistent Active Particles

, 2017
A lattice model for active matter is studied numerically, showing that it displays wettings transitions between three distinctive phases when in contact with an impenetrable wall. The particles in the model move persistently, tumbling with a small rate $\
Sepúlveda, Néstor, Soto, Rodrigo
core   +1 more source

Scintillation Type Alpha-Particle Detector

Review of Scientific Instruments, 1950
A portable scintillation detector for alpha-survey work is described. The instrument can detect as few as 16 alpha-counts (32 disintegrations) per minute because of the virtual elimination of spurious background. The upper limit of 50,000 counts per minute is not inherent and can be raised by appropriate circuit changes. The instrument is stable and is
A S, GOLDIN, E R, ROHRER, R L, MACKLIN
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source