Results 81 to 90 of about 467,308 (290)

Geomagnetically trapped alpha particles [PDF]

open access: yes
Geomagnetically trapped alpha particles from Injun IV satellite ...
Krimigis, S. M., Van Allen, J. A.
core   +1 more source

Fission studies with 140 MeV $\bm{\alpha}$-Particles

open access: yes, 2009
Binary fission induced by 140 MeV $\alpha$-particles has been measured for $^{\rm nat}$Ag, $^{139}$La, $^{165}$Ho and $^{197}$Au targets. The measured quantities are the total kinetic energies, fragment masses, and fission cross sections. The results are
A. Buttkewitz   +12 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Scintillation Type Alpha-Particle Detector

open access: yesReview of Scientific Instruments, 1950
A portable scintillation detector for alpha-survey work is described. The instrument can detect as few as 16 alpha-counts (32 disintegrations) per minute because of the virtual elimination of spurious background. The upper limit of 50,000 counts per minute is not inherent and can be raised by appropriate circuit changes. The instrument is stable and is
A S, GOLDIN, E R, ROHRER, R L, MACKLIN
openaire   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

HEOS 1 helium observations in the solar wind [PDF]

open access: yes
Results of alpha-particle observations performed by the European satellite HEOS 1, in the period from December 9, 1968, to April 13, 1969, and from September 6, 1969, to April 15, 1970, are presented.
Bollea, D.   +4 more
core   +1 more source

D region formation [PDF]

open access: yes, 1965
Ionospheric absorption of charged particles and photons, and ionization by solar radiation, cosmic rays, and Lyman alpha ...
Aikin, A. C.
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

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