Results 141 to 150 of about 3,104,746 (304)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Multi-omics insights into copper sulfate toxicity in American shad (Alosa sapidissima): impacts on oxidative stress, cytoskeletal integrity, immune regulation, and gut–metabolism balance

Egyptian Journal of Aquatic Research
Copper sulfate is widely used in aquaculture to control parasitic diseases, however, its toxicological effects on American shad (Alosa sapidissima) remain poorly understood.
Yao Zheng, Jiajia Li, Ampeire Yona, Xiaofei Wang, Gangchun Xu   +4 more
doaj   +1 more source

Epithelial Sodium Channel Alpha Subunit (αENaC) Is Associated with Inverse Salt Sensitivity of Blood Pressure. [PDF]

Biomedicines, 2022
Xu P, Sudarikova AV, Ilatovskaya DV, Gildea JJ, Akhter M, Carey RM, Yue W, Jose PA, Felder RA.   +8 more
europepmc   +1 more source

A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX.

Neuron, 1990
S. Couturier, D. Bertrand, J. Matter, Maria-Clemencia Hernandez, S. Bertrand, N. Millar, S. Valera, T. Barkas, M. Ballivet   +8 more
semanticscholar   +1 more source

Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus [PDF]

, 2005
Persistent activation of GABAA receptors by extracellular GABA (tonic inhibition) plays a critical role in signal processing and network excitability in the brain.
Walker, M.C., Sperk, G., Scimemi, A., Semyanov, A., Kullmann, D.M.   +4 more
core  

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Extraction and Purification of R-Phycoerythrin Alpha Subunit from the Marine Red Algae Pyropia Yezoensis and Its Biological Activities. [PDF]

Molecules, 2021
Ulagesan S, Nam TJ, Choi YH.
europepmc   +1 more source

Image of the Beta Kappa Omega chapter of the Alpha Kappa Alpha sorority, n.d.

, 2016
This image shows a studio portrait of BKΩ chapter members who attended Wichita State University.Archival master image scanned in reflective mode as 48-bit RGB color TIFF using Epson 11000 XL.
Alpha Kappa Alpha
core  

Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption

Advanced Functional Materials, EarlyView.
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy, Kyle B. Meerbott, Lorenzo Travaglini, Garima S. Dobhal, Artur Sawicki, Marc R. Knecht, Tiffany R. Walsh, Dominic J. Glover   +7 more
wiley   +1 more source

The transcriptional activator of the bfp operon in EPEC (PerA) interacts with the RNA polymerase alpha subunit. [PDF]

Sci Rep, 2021
Lara-Ochoa C, González-Lara F, Romero-González LE, Jaramillo-Rodríguez JB, Vázquez-Arellano SI, Medrano-López A, Cedillo-Ramírez L, Martínez-Laguna Y, Girón JA, Pérez-Rueda E, Puente JL, Ibarra JA.   +11 more
europepmc   +1 more source