Results 171 to 180 of about 345,950 (317)

Annonaceous acetogenins mimic AA005 targets mitochondrial trifunctional enzyme alpha subunit to treat obesity in male mice. [PDF]

Nat Commun
Han B, Li ZM, Zhao XY, Liang K, Mao YQ, Zhang SL, Huang LY, Kong CY, Peng X, Chen HL, Huang JT, Wu ZX, Yao JQ, Cai PR, Zhang ZY, Zhang XM, Yao ZJ, Chen GQ, Wang LS.   +18 more
europepmc   +1 more source

Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles.

, 1991
Richard M. Mortensen, Mercedes Zubiaur, Eva J. Neer, Jonathan G. Seidman   +3 more
openalex   +2 more sources

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following Na⁺ restriction. [PDF]

J Physiol
Nickerson AJ, Sheng S, Cox NA, Szekely KG, Marciszyn AL, Lam T, Chen J, Gingras S, Kashlan OB, Kirabo A, Hughey RP, Ray EC, Kleyman TR.   +12 more
europepmc   +1 more source

Interleukin-2 Receptor Subunit Alpha [PDF]

, 2020
openaire   +1 more source

Inhibin .ALPHA., .BETA.A Subunit and Activin Type II Receptor mRNAs Are Expressed in Human Brain Tumors.

, 1995
R Demura, SAEKO TAJIMA, Tomoharu Suzuki, Rie Yajima, E Odagiri, Hiroshi Demura, Hidehito Kato, Takehiko Uchiyama, Osami Kubo, Kintomo Takakura   +9 more
openalex   +2 more sources

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Persistent Thrombotic Hemangioma With Organizing/Anastomosing Features: A Case Report of a Guanine Nucleotide-Binding Protein Alpha Subunit (GNA)-Mutated Cutaneous Vascular Lesion. [PDF]

Cureus
Bobkova S, Oldham EP, Loykasek P, Henderson CL, Shendrik I.   +4 more
europepmc   +1 more source

DNA Polymerase Alpha Subunit B Is a Binding Protein for Erlotinib Resistance in Non-Small Cell Lung Cancer. [PDF]

Cancers (Basel), 2020
Kim TY, Ji ES, Lee JY, Kim JY, Yoo JS, Szasz AM, Dome B, Marko-Varga G, Kwon HJ.   +8 more
europepmc   +1 more source

Faculty Opinions recommendation of Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors.

, 2008
Titia K. Sixma
openalex   +2 more sources